{"product_id":"recombinant-human-cd93-c1qr1-protein-aa-1-580-his-tag-pksh030806","title":"Recombinant Human CD93\/C1QR1 Protein (aa 1-580, His Tag) - PKSH030806","description":"\u003cp\u003eRecombinant Human CD93\/C1QR1 Protein (aa 1-580, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH030806-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CD93; C1QR1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Complement Component C1q Receptor; C1q\/MBL\/SPA Receptor; C1qR; C1qR(p); C1qRp; CDw93; Complement Component 1 q Subcomponent Receptor 1; Matrix-Remodeling-Associated Protein 4CD93; C1QR1; MXRA4\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9NPY3\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular; immunology; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9NPY3\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD93 or C1q receptor 1 (C1qR) is an about 120 kDa O-sialoglycoprotein that within the hematopoietic system is selectively expressed on cells of the myeloid lineage. CD93\/C1qR is a highly glycosylated transmembrane protein expressed on monocytes; neutrophils; endothelial cells; and stem cells. CD93 was originally identified as a myeloid cell-surface marker and subsequently associated with an ability to modulate phagocytosis of suboptimally opsonized immunoglobulin G and complement particles in vitro. CD93\/C1qR; a receptor expressed during early B-cell development; is reinduced during plasma-cell differentiation. High CD93\/CD138 expression was restricted to antibody-secreting cells both in T-dependent and T-independent responses as naive; memory; and germinal-center B cells remained CD93-negative. CD93 was expressed on (pre)plasmablasts\/plasma cells; including long-lived plasma cells that showed decreased cell cycle activity; high levels of isotype-switched Ig secretion; and modification of the transcriptional network. CD93 is important for the maintenance of plasma cells in bone marrow niches.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Lys 580\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 59.6 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 100 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43083643355315,"sku":"PKSH030806-50","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_9ab2879b-287f-43e1-b3bf-4b9d775ec388.png?v=1708945959","url":"https:\/\/afsbio.com\/products\/recombinant-human-cd93-c1qr1-protein-aa-1-580-his-tag-pksh030806","provider":"AFSBio Inc.","version":"1.0","type":"link"}