{"product_id":"recombinant-human-cdcp1-cd318-protein-fc-tag-pksh030671","title":"Recombinant Human CDCP1\/CD318 Protein (Fc Tag) - PKSH030671","description":"\u003cp\u003eRecombinant Human CDCP1\/CD318 Protein (Fc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030671-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CDCP1, CD318\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: CUB domain-containing protein 1, Membrane glycoprotein gp140, Subtractive immunization M plus HEp3-associated 135 kDa protein, SIMA135, Transmembrane and associated with src kinases, CD318, TRASK\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9H5V8\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-mFc\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9H5V8-3\u003c\/p\u003e\n\n\u003cp\u003eBackground: CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and in both, typical and atypical (cancerous) colons. It interacts with CDH2\/N-cadherin, CDH3\/P-cadherin, SDC1\/syndecan-1, SDC4\/syndecan-4 and the serine protease ST14\/MT-SP1. It also interacts with SRC and PRKCG\/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF\/EGFR-induced cell migration. It has been shown that signaling via EGF\/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and for immature hematopoietic stem cell subsets.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Glu343\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 61.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 89-93 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43155065438387,"sku":"PKSH030671-50","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_658eaa4b-1c44-407c-83e9-eb8bf54fa11a.png?v=1710438324","url":"https:\/\/afsbio.com\/products\/recombinant-human-cdcp1-cd318-protein-fc-tag-pksh030671","provider":"AFSBio Inc.","version":"1.0","type":"link"}