{"product_id":"recombinant-human-cdcp1-gp140-cd318-protein-rp01539","title":"Recombinant Human CDCP1\/gp140\/CD318 Protein - RP01539","description":"\u003cp\u003eRecombinant Human CDCP1\/gp140\/CD318 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01539-10, RP01539-20, RP01539-50, RP01539-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human CDCP1\/gp140\/CD318 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Phe30-Leu666) of human gp140\/CDCP1\/CD318 (Accession #NP_073753.3) fused with a hFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD318, TRASK, SIMA135, CDCP1, SIMA135, TRASK\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q9H5V8-1\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 64866\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: CDCP1 contains three extracellular CUB domains. It is a putative stem cell marker that is highly expressed in some human cancer cells and both, typical and atypical (cancerous) colons. It interacts with CDH2\/N-cadherin, CDH3\/P-cadherin, SDC1\/syndecan-1, SDC4\/syndecan-4 and the serine protease ST14\/MT-SP1. It also interacts with SRC and PRKCG\/protein kinase C gamma. CDCP1 is taken as a key regulator of EGF\/EGFR-induced cell migration. It has been shown that signaling via EGF\/EGFR induces migration of ovarian cancer Caov3 and OVCA420 cells with concomitant up-regulation of CDCP1 mRNA and protein. Consistent with a role in cell migration CDCP1 relocates from cell-cell junctions to punctate structures on filopodia after activation of EGFR. It may be involved in cell adhesion and cell matrix association. It also may play a role in the regulation of anchorage versus migration or proliferation versus differentiation via its phosphorylation. It has been taken as a novel marker for leukemia diagnosis and immature hematopoietic stem cell subsets.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized Human CDH3 (Catalog #RP01491) at 5 μg\/mL (100 μL\/well) can bind Human CDCP1 (Catalog #RP01539) with a linear range of 0.37-3.05 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: FEIALPRESNITVLIKLGTPTLLAKPCYIVISKRHITMLSIKSGERIVFTFSCQSPENHFVIEIQKNIDCMSGPCPFGEVQLQPSTSLLPTLNRTFIWDVKAHKSIGLELQFSIPRLRQIGPGESCPDGVTHSISGRIDATVVRIGTFCSNGTVSRIKMQEGVKMALHLPWFHPRNVSGFSIANRSSIKRLCIIESVFEGEGSATLMSANYPEGFPEDELMTWQFVVPAHLRASVSFLNFNLSNCERKEERVEYYIPGSTTNPEVFKLEDKQPGNMAGNFNLSLQGCDQDAQSPGILRLQFQVLVQHPQNESNKIYVVDLSNERAMSLTIEPRPVKQSRKFVPGCFVCLESRTCSSNLTLTSGSKHKISFLCDDLTRLWMNVEKTISCTDHRYCQRKSYSLQVPSDILHLPVELHDFSWKLLVPKDRLSLVLVPAQKLQQHTHEKPCNTSFSYLVASAIPSQDLYFGSFCPGGSIKQIQVKQNISVTLRTFAPSFQQEASRQGLTVSFIPYFKEEGVFTVTPDTKSKVYLRTPNWDRGLPSLTSVSWNISVPRDQVACLTFFKERSGVVCQTGRAFMIIQEQRTRAEEIFSLDEDVLPKPSFHHHSFWVNISNCSPTSGKQLDLLFSVTLTPRTVDL\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198330167475,"sku":"RP01539-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198330200243,"sku":"RP01539-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198330233011,"sku":"RP01539-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198330265779,"sku":"RP01539-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_bbfb302f-25cd-477c-8028-de9c2656c7b2.png?v=1766960666","url":"https:\/\/afsbio.com\/products\/recombinant-human-cdcp1-gp140-cd318-protein-rp01539","provider":"AFSBio Inc.","version":"1.0","type":"link"}