{"product_id":"recombinant-human-cerebral-dopamine-neurotrophic-factor-cdnf-protein-rp01747","title":"Recombinant Human Cerebral dopamine neurotrophic factor\/CDNF Protein - RP01747","description":"\u003cp\u003eRecombinant Human Cerebral dopamine neurotrophic factor\/CDNF Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01747-10, RP01747-20, RP01747-50, RP01747-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Cerebral dopamine neurotrophic factor\/ CDNF Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln27-Leu187) of human Cerebral dopamine neurotrophic factor\/ CDNF (Accession #NP_001025125.2) fused with and a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ARMETL1; Cerebral dopamine neurotrophic factor; CDNF\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q49AH0\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 441549\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cerebral Dopamine Neurotrophic Factor (CDNF), also known as ARMETL1 (ARMET-like protein 1), is a secreted protein with eight conserved cysteine residues, predicting a unique protein fold and defining a new, evolutionarily conserved protein family. CDNF is a novel neurotrophic factor with strong trophic activity on dopaminergic neurons comparable to that of glial cell line-derived neurotrophic factor (GDNF). CDNF\/ARMETL1 is a evolutionary conserved protein which can protect and restore the function of dopaminergic neurons in the rat model of Parkinson's disease, suggesting that CDNF might be beneficial for the treatment of Parkinson's disease. CDNF is widely expressed in neurons in several brain regions including cerebral cortex, hippocampus, substantia nigra, striatum and cerebellum. Human CDNF is glycosylated and secreted from transiently transfected cells. CDNF promotes the survival, growth, and function of dopamine-specific neurons and is expressed in brain regions that undergo cocaine-induced neuroplasticity.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QEAGGRPGADCEVCKEFLNRFYKSLIDRGVNFSLDTIEKELISFCLDTKGKENRLCYYLGATKDAATKILSEVTRPMSVHMPAMKICEKLKKLDSQICELKYEKTLDLASVDLRKMRVAELKQILHSWGEECRACAEKTDYVNLIQELAPKYAATHPKTEL\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198243561651,"sku":"RP01747-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198243594419,"sku":"RP01747-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198243627187,"sku":"RP01747-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198243659955,"sku":"RP01747-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_50b80f78-553b-4a04-b139-b340a00a7dfb.png?v=1766959647","url":"https:\/\/afsbio.com\/products\/recombinant-human-cerebral-dopamine-neurotrophic-factor-cdnf-protein-rp01747","provider":"AFSBio Inc.","version":"1.0","type":"link"}