{"product_id":"recombinant-human-chemerin-rarres2-protein-rp01808","title":"Recombinant Human Chemerin\/RARRES2 Protein - RP01808","description":"\u003cp\u003eRecombinant Human Chemerin\/RARRES2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01808-10, RP01808-20, RP01808-50, RP01808-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Chemerin\/RARRES2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu21-Ser157) of human RARRES2\/TIG2 (Accession #) fused with hFc tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: TIG2; HP10433; RARRES2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q99969\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 5919\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Retinoic acid receptor responder protein 2 (RARRES2) is a small secreted protein involved in multiple cancers, including adrenocortical carcinoma (ACC). Serum RARRES2 may be used as a novel prognostic marker for ACC. Retinoic acid receptor responder 2 (RARRES2) is transcriptionally downregulated in multiple cancer types. Previous studies suggested that it can serve as an immune-dependent tumor suppressor by acting as a chemoattractant to recruit anticancer immune cells expressing its receptor, the chemerin chemokine receptor 1 (CMKLR1), to sites of tumor. Mechanistically, RARRES2 overexpression in ACC cells inhibited Wnt\/beta-catenin pathway activity by promoting beta-catenin phosphorylation and degradation, it also inhibited the phosphorylation of p38 mitogen-activated protein kinase. Thus RARRES2 is a novel tumor suppressor for ACC, which can function through an immune-independent mechanism.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFC\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: ELTEAQRRGLQVALEEFHKHPPVQWAFQETSVESAVDTPFPAGIFVRLEFKLQQTSCRKRDWKKPECKVRPNGRKRKCLACIKLGSEDKVLGRLVHCPIETQVLREAEEHQETQCLRVQRAGEDPHSFYFPGQFAFS\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.01 EU\/μg of the protein by LAL method\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198267941043,"sku":"RP01808-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198267973811,"sku":"RP01808-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198268006579,"sku":"RP01808-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198268039347,"sku":"RP01808-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_f17a78e1-6a43-473e-9a3f-a238e6ea43ae.png?v=1766959922","url":"https:\/\/afsbio.com\/products\/recombinant-human-chemerin-rarres2-protein-rp01808","provider":"AFSBio Inc.","version":"1.0","type":"link"}