{"product_id":"recombinant-human-cndp1-protein-his-tagactive-pksh031891","title":"Recombinant Human CNDP1 Protein (His Tag)(Active) - PKSH031891","description":"Recombinant Human CNDP1 Protein (His Tag)(Active)\n\nSize: 50μg\n\nCatalogue Number: PKSH031891-50\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: CNDP1\n\nTarget Symptom: Beta-Ala-His Dipeptidase; CNDP Dipeptidase 1; Carnosine Dipeptidase 1; Glutamate Carboxypeptidase-Like Protein 2; Serum Carnosinase; CNDP1; CN1; CPGL2; HsT2308\n\nResearch Area: Signal Transduction; Cancer; \n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Enzyme\n\nFusion Tag: C-His\n\nAccession: NP_116038.4\n\nBackground: CNDP1; also known as carnosine dipeptidase 1; glutamate carboxypeptidase-like protein 2 (CPGL-2) or carnosinase 1 (CN1); is a member of the M20 metalloprotease family. The CNDP1 gene contains trinucleotide (CTG) repeat length polymorphism in the coding region; which has been demonstrated to be associated with susceptibility to developing diabetic nephropathy; for carnosine protection against the adverse effects of high glucose levels on renal cells. In humans; CNDP1 is secreted from the liver into the serum. In other mammals; including rodents; CNDP1 is expressed exclusively within the kidney and lacks a signal peptide. CNDP1 protein is a secreted homodimeric dipeptidase that specifically hydrolyzes L-carnosine (β -alanyl-L-histidine); and is identified as human carnosinase expressed in the brain. CNDP1 has been associated with diabetic nephropathy in Europeans and European Americans; but not African-Americans. It was identified and confirmed as a risk factor; were cross-sectional and mostly in patients with type 2 diabetes. The polymorphisms of CNDP1 can be excluded as a risk factor for nephropathy in type 1 diabetes. In addition; CNDP1 is also suggested to be implicated in the actions of neuroprotection and neurotransmiting.\n\nActivity: Measured by its ability to cleave carnosine (β­Ala­L­His) in a two­step assay. The specific activity is \u0026gt; 250 pmoles\/min\/μg.\n\nSequence: Ser27-His507\n\nPurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4 \nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 55.3 kDa\n\nObserved MW: 60-65 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104329728179,"sku":"PKSH031891-50","price":1213.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_470c8f05-a399-42a1-be1a-7cbd3a1619eb.png?v=1709294456","url":"https:\/\/afsbio.com\/products\/recombinant-human-cndp1-protein-his-tagactive-pksh031891","provider":"AFSBio Inc.","version":"1.0","type":"link"}