{"product_id":"recombinant-human-contactin-2-cntn2-protein-his-tagactive-pksh031598","title":"Recombinant Human Contactin 2\/CNTN2 Protein (His Tag)(Active) - PKSH031598","description":"Recombinant Human Contactin 2\/CNTN2 Protein (His Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031598-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: Contactin 2; CNTN2\n\nTarget Symptom: Contactin-2; Axonal glycoprotein TAG-1; Axonin-1; Transient axonal glycoprotein 1; CNTN2; AXT; TAG1; TAX1\n\nResearch Area: Neuroscience; Cancer\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Cell culture; ELISA\n\nFusion Tag: C-His\n\nAccession: NP_005067.1\n\nBackground: Contactins are a subgroup of molecules belonging to the immunoglobulin superfamily that are expressed exclusively in the nervous system. The subgroup consists of six members: Contactin-1, Contactin-2(TAG-1), Contactin-3(BIG-1), BIG-2, Contactin-5(NB-2) and NB-3. Axonal expression and the neurite extension activity of Contactin-1 and Contactin-2 attracted researchers to study the function of these molecules in axon guidance during development. Contactin-1 and Contactin-2 have come to be known as the principal molecules in the function and maintenance of myelinated neurons. Contactin-2, also known as CNTN2, is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. Contactin-2 is expressed by a subset of neuronal populations in the developing central nervous system (CNS) and peripheral nervous system (PNS). Contactin-2 is also expressed by oligodendrocytes and Schwann cells, which are myelinating glial cells of the CNS and PNS, respectively. Contactin-2 may play a role in the formation of axon connections in the developing nervous system. Contactin-2 is also involved in glial tumorigenesis and may provide a potential target for therapeutic intervention. During embryonic development, Contactin-2 interacts either in a homophilic, or heterophilic fashion with various transmembrane proteins.\n\nActivity: Measured by the ability of the immobilized protein to support the adhesion of C6 Rat brain glial cells. When 5 x 10\u003csup\u003e4\u003c\/sup\u003e cells\/well are added to CNTN2-coated plates (0.8 μg\/ml and 100 μl\/well), approximately 40%-60% will adhere specifically after 60 minutes at 37℃.\n\nSequence: Met 1-Asn 1012\n\nPurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile 100mM Glycine, 10mM NaCl, 50mM Tris, pH 7.5\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 109 kDa\n\nObserved MW: 140 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104317964467,"sku":"PKSH031598-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_810f2cb9-d91e-49d1-a641-a311153e81ca.png?v=1709294186","url":"https:\/\/afsbio.com\/products\/recombinant-human-contactin-2-cntn2-protein-his-tagactive-pksh031598","provider":"AFSBio Inc.","version":"1.0","type":"link"}