{"product_id":"recombinant-human-cradd-raidd-protein-his-tag-pksh030770","title":"Recombinant Human CRADD\/RAIDD Protein (His Tag) - PKSH030770","description":"\u003cp\u003eRecombinant Human CRADD\/RAIDD Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH030770-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CRADD; RAIDD\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Death Domain-Containing Protein CRADD; Caspase and RIP Adapter with Death Domain; RIP-Associated Protein with A Death Domain; CRADD; RAIDD\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P78560\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P78560\u003c\/p\u003e\n\n\u003cp\u003eBackground: Death domain-containing protein CRADD; also known as Caspase and RIP adapter with death domain; RIP-associated protein with a death domain; CRADD and RAIDD; is a protein which is constitutively expressed in most tissues; with particularly high expression in adult heart; testis; liver; skeletal muscle; fetal liver and kidney. CRADD \/ RAIDD contains oneCARD domain and onedeath domain. CRADD \/ RAIDD contains a death domain involved in the binding of RIP protein. The CARD domain mediates the interaction with caspase-2. FADD \/ MORT1 is a death domain (DD)-containing adaptor \/ signaling molecule that interacts with the intracellular DD of FAS \/ APO-I ( CD95 ) and tumor necrosis factor receptor 1 and the prodomain of caspase-8 ( Mch5 \/ MACH \/ FLICE). CRADD \/ RAIDD has a dual-domain structure similar to that of FADD. CRADD \/ RAIDD has an NH2-terminal caspase homology domain that interacts with caspase-2 and a COOH-terminal DD that interacts with RIP. CRADD \/ RAIDD could play a role in regulating apoptosis in mammalian cells. CRADD \/ RAIDD is a apoptotic adaptor molecule specific for caspase-2 and FASL \/ TNF receptor-interacting protein RIP. In the presence of RIP and TRADD; CRADD \/ RAIDD recruits caspase-2 to the TNFR-1 signalling complex.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Glu 199\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, 20% glycerol, pH 8.0\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 24.1 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 26 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083642962099,"sku":"PKSH030770-100","price":1197.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c7b3a5eb-263f-4329-900f-48ce3b070320.png?v=1708945943","url":"https:\/\/afsbio.com\/products\/recombinant-human-cradd-raidd-protein-his-tag-pksh030770","provider":"AFSBio Inc.","version":"1.0","type":"link"}