{"product_id":"recombinant-human-ctla4-protein-fc-avi-tagactive-pksh033803","title":"Recombinant Human CTLA4 Protein (Fc \u0026 Avi Tag)(Active) - PKSH033803","description":"\u003cp\u003eRecombinant Human CTLA4 Protein (Fc \u0026amp; Avi Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033803-20, PKSH033803-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: CTLA4\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Cytotoxic T-lymphocyte protein 4; Cytotoxic T-lymphocyte-associated antigen 4; CTLA4; CD152; Cytotoxic T-Lymphocyte-Associated Protein 4\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: immunology; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eConjugation: Biotinylated\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc-Avi\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P16410\u003c\/p\u003e\n\n\u003cp\u003eAccession: P16410\u003c\/p\u003e\n\n\u003cp\u003eBackground: Cytotoxic T-lymphocyte protein 4; is a single-pass type I membrane protein. It is widely expressed with highest levels in lymphoid tissues. CD28 and CTLA-4; together with their ligands; B7-1 and B7-2; constitute one of the dominant costimulatory pathways that regulate T and B cell responses. CD28 and CTLA-4 are structurally homologous molecules that are members of the immunoglobulin (Ig) gene superfamily. CTLA4 transmits an inhibitory signal to T cells; whereas CD28 transmits a stimulatory signal. Intracellular CTLA4 is also found in regulatory T Cells and may play an important role in their functions. Tcell activation through the Tcell receptor and CD28 leads to increased expression of CTLA4.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human CTLA-4-Fc-Avi at 2μg\/ml(100 μl\/well) can bind Human B7-2-6His(Cat: PKSH033722). The ED50 of Human CTLA-4-Fc-Avi is 1. 98 ug\/mL\u003c\/p\u003e\n\n\u003cp\u003eSequence: Lys36-Asp161\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 41.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 57-60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43118160150707,"sku":"PKSH033803-20","price":478.8,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43118160183475,"sku":"PKSH033803-100","price":1293.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_d8c41dff-ab16-41f0-a15b-240fe4b46e78.png?v=1709637311","url":"https:\/\/afsbio.com\/products\/recombinant-human-ctla4-protein-fc-avi-tagactive-pksh033803","provider":"AFSBio Inc.","version":"1.0","type":"link"}