{"product_id":"recombinant-human-cx3cl1-fractalkine-protein-rp01711","title":"Recombinant Human CX3CL1\/Fractalkine Protein - RP01711","description":"\u003cp\u003eRecombinant Human CX3CL1\/Fractalkine Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20ug, 50ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01711-10, RP01711-20, RP01711-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human CX3CL1\/Fractalkine Protein is produced by Pichia expression system. The target protein is expressed with sequence (Gln25-Gly100) of human CX3CL1\/Fractalkine (Accession #NP_002987.1) fused with and a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: NTN; NTT; CXC3; CXC3C; SCYD1; ABCD-3; C3Xkine; fractalkine; neurotactin\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P78423\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6376\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Fractalkine or Chemokine (C-X3-C motif) ligand 1 (CX3CL1) is a member of the CX3C chemokine family. Fractalkine \/ CX3CL1 is a unique chemokine that functions not only as a chemoattractant but also as an adhesion molecule and is expressed on endothelial cells activated by proinflammatory cytokines, such as interferon-gamma and tumor necrosis factor-alpha. Fractalkine\/CX3CL1 is expressed in a membrane-bound form on activated endothelial cells and mediates attachment and firm adhesion of T cells, monocytes and NK cells. Fractalkine \/ CX3CL1 is associated with dendritic cells (DC) in epidermis and lymphoid organs. The fractalkine receptor, CX3CR1, is expressed on cytotoxic effector lymphocytes, including natural killer (NK) cells and cytotoxic T lymphocytes, which contain high levels of intracellular perforin and granzyme B, and on macrophages. Soluble fractalkine causes migration of NK cells, cytotoxic T lymphocytes, and macrophages, whereas the membrane-bound form captures and enhances the subsequent migration of these cells in response to secondary stimulation with other chemokines.\u003c\/p\u003e\n\n\u003cp\u003eSource: Pichia\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QHHGVTKCNITCSKMTSKIPVALLIHYQQNQASCGKRAIILETRQHRLFCADPKEQWVKDAMQHLDRQAAALTRNG\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198363984051,"sku":"RP01711-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198364016819,"sku":"RP01711-20","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198364049587,"sku":"RP01711-50","price":350.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_b7ddec6c-0ad2-46f0-befa-b23bb37a8bbc.png?v=1766961225","url":"https:\/\/afsbio.com\/products\/recombinant-human-cx3cl1-fractalkine-protein-rp01711","provider":"AFSBio Inc.","version":"1.0","type":"link"}