{"product_id":"recombinant-human-cxcl12-sdf-1-protein-rp01637","title":"Recombinant Human CXCL12\/SDF-1 Protein - RP01637","description":"\u003cp\u003eRecombinant Human CXCL12\/SDF-1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01637-10, RP01637-20, RP01637-50, RP01637-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human CXCL12\/SDF-1 Protein is produced by Pichia expression system. The target protein is expressed with sequence (Lys22-Lys89) of human CXCL12\/SDF-1 (Accession #NP_954637.1.) fused with no additional amino acid.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IRH; PBSF; SDF1; TLSF; TPAR1; SCYB12; CXCL12\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P48061-2\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 6387\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A\/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to chemoattract MOLT4 cells. The ED50 for this effect is 11.47-45.86 ng\/mL, corresponding to a specific activity of 2.18×10^4 ~8.72×10^4 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: Pichia\u003c\/p\u003e\n\n\u003cp\u003eTag: NO-tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: KPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKNNNRQVCIDPKLKWIQEYLEKALNK\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198347042995,"sku":"RP01637-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198347075763,"sku":"RP01637-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198347108531,"sku":"RP01637-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198347141299,"sku":"RP01637-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_d4deb668-6f38-4696-b3b7-cc838a1e8ff0.png?v=1766960873","url":"https:\/\/afsbio.com\/products\/recombinant-human-cxcl12-sdf-1-protein-rp01637","provider":"AFSBio Inc.","version":"1.0","type":"link"}