{"product_id":"recombinant-human-cynomolgus-rhesus-macaque-cd28-protein-rp00136","title":"Recombinant Human\/Cynomolgus\/Rhesus macaque CD28 Protein - RP00136","description":"\u003cp\u003eRecombinant Human\/Cynomolgus\/Rhesus macaque CD28 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00136-10, RP00136-20, RP00136-50, RP00136-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human\/Cynomolgus\/Rhesus macaque CD28 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Asn19-Pro152) of human CD28\/TP44 (Accession #NP_006130.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD28, Tp44\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P10747\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 940\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human,Cynomolgus,Rhesus macaque\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR\/CD3 ligation and CD40L costimulation. Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA. Immobilized Human CD28 Protein at 1 μg\/mL (100 μL\/well) can bind CD28 Rabbit mAb with a linear range of 0.06-1.04 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: NKILVKQSPMLVAYDNAVNLSCKYSYNLFSREFRASLHKGLDSAVEVCVVYGNYSQQLQVYSKTGFNCDGKLGNESVTFYLQNLYVNQTDIYFCKIEVMYPPPYLDNEKSNGTIIHVKGKHLCPSPLFPGPSKP\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198300479667,"sku":"RP00136-10","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198300512435,"sku":"RP00136-20","price":189.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198300545203,"sku":"RP00136-50","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198300577971,"sku":"RP00136-100","price":336.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_ce970c94-96d5-4b32-b6b5-e89f895820c6.png?v=1766960321","url":"https:\/\/afsbio.com\/products\/recombinant-human-cynomolgus-rhesus-macaque-cd28-protein-rp00136","provider":"AFSBio Inc.","version":"1.0","type":"link"}