{"product_id":"recombinant-human-dc-sign-cd209-n-fc-pksh033989","title":"Recombinant Human DC-SIGN\/CD209 (N-Fc) - PKSH033989","description":"\u003cp\u003eRecombinant Human DC-SIGN\/CD209 (N-Fc)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033989-10, PKSH033989-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: DC-SIGN; CD209\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: CD209 molecule; CD209; CDSIGNHIV gpl20-binding protein; CLEC4L; DCSIGN; DC-SIGN; DC-SIGN1; CD209 Antigen\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Microbiology; immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9NNX6\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9NNX6\u003c\/p\u003e\n\n\u003cp\u003eBackground: CD209 is also known as CLEC4L, DC-SIGN and CD209 antigen, is a type II transmembrane protein on DCs with a C-type lectin extracellular domain, is capable of binding ICAM-3 on resting T cells in the secondary lymphoid organs, providing the initial contact between these cells during the establishment of cell-mediated immunity. The DC-SIGN\/CD209 lectin domain binds mannose oligosaccharides on pathogens including HIV as well as self glycoproteins including ICAMs (2, 4). DC-SIGN\/CD209 binds to butyrophilin 2A1 and this interaction can be blocked by HIV pp120. DC-SIGN\/CD209 is expressed on dendritic cells (DC) and inflammatory macrophages and contributes to antigen presentation. It is not only a pattern recognition receptor but implicated in immunoregulation of DCs. It has important role in mediating DC adhesion, migration, inflammation, activating primary T cell, triggering immune response and participating in immune escape of pathogens and tumors.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Gln59-Ala404\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 65.3 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 75 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43114008969395,"sku":"PKSH033989-10","price":184.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43114009002163,"sku":"PKSH033989-50","price":550.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_65320bf0-c261-42ca-90dc-4e2d94fd390b.png?v=1709550151","url":"https:\/\/afsbio.com\/products\/recombinant-human-dc-sign-cd209-n-fc-pksh033989","provider":"AFSBio Inc.","version":"1.0","type":"link"}