{"product_id":"recombinant-human-deoxycytidine-kinase-dck-protein-his-t7-tag-pksh032348","title":"Recombinant Human Deoxycytidine Kinase\/DCK Protein (His \u0026T7 Tag) - PKSH032348","description":"\u003cp\u003eRecombinant Human Deoxycytidine Kinase\/DCK Protein (His \u0026amp;T7 Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032348-10, PKSH032348-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Deoxycytidine Kinase; DCK\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Deoxycytidine Kinase; dCK; DCK\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P27707\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P27707\u003c\/p\u003e\n\n\u003cp\u003eBackground: Deoxycytidine Kinase (DCK) is a member of the DCK\/DGK family. DCK exists as a homodimer and is localized to the nucleus. DCK is required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG), and deoxyadenosine (dA). DCK has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. In addition, DCK is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents. DCK is clinically important because of its relationship to drug resistance and sensitivity.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Leu260\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, pH7.5.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 34.0 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 30 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43092768555187,"sku":"PKSH032348-10","price":368.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43092768587955,"sku":"PKSH032348-50","price":684.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_10acc49a-432e-4f3b-b714-583ddfc92dfd.png?v=1709119584","url":"https:\/\/afsbio.com\/products\/recombinant-human-deoxycytidine-kinase-dck-protein-his-t7-tag-pksh032348","provider":"AFSBio Inc.","version":"1.0","type":"link"}