{"product_id":"recombinant-human-diamine-oxidase-aoc1-protein-his-tag-pksh032352","title":"Recombinant Human Diamine Oxidase\/AOC1 Protein (His Tag) - PKSH032352","description":"\u003cp\u003eRecombinant Human Diamine Oxidase\/AOC1 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032352-10, PKSH032352-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Diamine Oxidase; AOC1\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Amiloride-sensitive amine oxidase [copper-containing]; DAO; Diamine oxidase; Amiloride-binding protein 1; Amine oxidase copper domain-containing protein 1; Histaminase; Kidney amine oxidase; KAO; AOC1; ABP1; DAO1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P19801\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P19801\u003c\/p\u003e\n\n\u003cp\u003eBackground: Amiloride-sensitive amine oxidase (AOC1) belongs to the copper\/topaquinone oxidase family. The protein exists as homodimer by disulfide and mainly located in placenta and kidney. AOC1 catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. Placental DAO is thought to play a role in the regulation of the female reproductive function. The activity of this protein can be inhibited by amiloride in a competitive manner. It is inhibited by amiloride, a diuretic that acts by closing epithelial sodium ion channels.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Glu20-Val751\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 150mM NaCl, 10% Glycerol, pH7.5.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 84.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 90 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43092769079475,"sku":"PKSH032352-10","price":292.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43092769112243,"sku":"PKSH032352-50","price":459.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_566d3692-7001-48fb-ae28-93676ee4a329.png?v=1709119599","url":"https:\/\/afsbio.com\/products\/recombinant-human-diamine-oxidase-aoc1-protein-his-tag-pksh032352","provider":"AFSBio Inc.","version":"1.0","type":"link"}