{"product_id":"recombinant-human-dusp14-mkp-6-protein-his-mbp-tag-pksh030837","title":"Recombinant Human DUSP14\/MKP-6 Protein (His \u0026 MBP Tag) - PKSH030837","description":"\u003cp\u003eRecombinant Human DUSP14\/MKP-6 Protein (His \u0026amp; MBP Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH030837-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: DUSP14; MKP-6\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: MKP-L; MKP6\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O95147\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His \u0026amp; MBP\u003c\/p\u003e\n\n\u003cp\u003eAccession: O95147\u003c\/p\u003e\n\n\u003cp\u003eBackground: Dual specific phosphatase 14 \/ MAP-kinase phophatase-6 (DUSP14 \/ MKP6) is a member of Dual-specificity phosphatases that is a subclass of protein tyrosine phosphatases (PTP) families that can dephosphorylate bothe phosphotyrosine and phosphoserine \/ phosphothreonine residues in substrates. Unlike many other DUSPs, DUSP14 only contains a catalytic domain within the C-terminal region. In signal transduction, DUSP14 has been considered as negative regulator of the mitogen-activated protein kinase (MAPK) \/ extracellular signal-regulated kinase 1 \/ 2 (ERK 1 \/ 2) pathway. DUSP14 phosphatase activity has been confirmed to be inhibited by PTP inhibitor Ⅳ. PTP inhibitor binds to the catalytic site of DUSP14. PTP inhibitor Ⅳ effectively and specifically inhibited DUSP14-mediated dephosphorylation of JNK, a member of the mitogen-activated protein kinase (MAPK) family through dephosphorylation of both the Ser \/ Thr and Tyr residues of MAPKs.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1 –His 191\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 88 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.5\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 65 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083643977907,"sku":"PKSH030837-100","price":1197.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_431f2b44-2715-4f7b-85bb-5eaad792d17d.png?v=1708945982","url":"https:\/\/afsbio.com\/products\/recombinant-human-dusp14-mkp-6-protein-his-mbp-tag-pksh030837","provider":"AFSBio Inc.","version":"1.0","type":"link"}