{"product_id":"recombinant-human-e2f2-protein-his-tag-pdeh100410","title":"Recombinant Human E2F2 protein (His tag) - PDEH100410","description":"\u003cp\u003eRecombinant Human E2F2 protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEH100410-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: E2F2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Transcription factor E2F2; E2F2;\u003c\/p\u003e \n\n\u003cp\u003eUNIProt ID: Q14209\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Epigenetics and Nuclear signaling\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q14209\u003c\/p\u003e\n\n\u003cp\u003eBackground: E2F-2 (viral E2-associated factor 2) is a 50-55 kDa member of the E2F\/DP family of transcription factors. It is principally expressed by placenta, and forms a DNA-activating E2F heterodimeric complex with DP-1 or -2. This complex, when active, promotes cell cycle progression. In quiescent cells, association with the retinoblastoma-tumor suppressor gene product termed pRB suppresses its activity. Human E2F-2 is 437 amino acids (aa) in length and contains a CDK2 binding region (aa 65-105), a DNA-binding domain (aa 107-196), a dimerization segment (aa 197-289), a transactivation region (aa 359-437), and a pRB binding domain (aa 410-427). There are two potential alternate start sites at Met197 and Met342, and one splice variant that shows a two aa substitution for aa 349-437.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala 65-Asn 437\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 40.92 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 55 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083559305395,"sku":"PDEH100410-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8e0baac9-5e81-482c-b64f-5c96bbccaa4c.png?v=1708944682","url":"https:\/\/afsbio.com\/products\/recombinant-human-e2f2-protein-his-tag-pdeh100410","provider":"AFSBio Inc.","version":"1.0","type":"link"}