{"product_id":"recombinant-human-ednrb-endothelin-b-receptor-protein-fc-tag-pksh030546","title":"Recombinant Human EDNRB\/Endothelin B Receptor Protein (Fc Tag) - PKSH030546","description":"\u003cp\u003eRecombinant Human EDNRB\/Endothelin B Receptor Protein (Fc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH030546-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: EDNRB, Endothelin B Receptor\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: ABCDS, ET-B, ET-BR, ETB, ETBR, ETRB, HSCR, HSCR2, WS4A\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction,\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-mFc\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_000106.1\u003c\/p\u003e\n\n\u003cp\u003eBackground: The hypermethylation of EDNRB gene was remarkably related to infiltration and metastasis of gastric cancer and may attribute to the tumor progression. EDNRB is a new candidate tumor suppressor gene which is often down-regulated or even silenced by promoter hypermethylation in various human cancers. Low EDNRB expression played a role in the progression of ACC tumors. The autosomal recessive mutation in EDNRB may underlie a part of WS1 with the current diagnostic criteria, and supported that Hirschsprung's disease is a multifactorial genetic disease which requires additional factors.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Lys101\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 85 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4 \u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 34.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 47.5 and 43.7 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43155023331507,"sku":"PKSH030546-100","price":1197.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_fba706b8-3ea0-47cc-9a5b-1f2aab787a85.png?v=1710436759","url":"https:\/\/afsbio.com\/products\/recombinant-human-ednrb-endothelin-b-receptor-protein-fc-tag-pksh030546","provider":"AFSBio Inc.","version":"1.0","type":"link"}