{"product_id":"recombinant-human-egfr-erbb1-protein-fc-tagactive-pksh031995","title":"Recombinant Human EGFR\/ErbB1 Protein (Fc Tag)(Active) - PKSH031995","description":"Recombinant Human EGFR\/ErbB1 Protein (Fc Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031995-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: EGFR; ErbB1\n\nTarget Symptom: ERBB; ERBB1; HER1; mENA; NISBD2; PIG61\n\nResearch Area: Signal Transduction; Cancer; \n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: ELISA\n\nFusion Tag: C-hFc\n\nAccession: NP_005219\n\nBackground: As a member of the epidermal growth factor receptor (EGFR) family; EGFR protein is type I transmembrane glycoprotein that binds a subset of EGF family ligands including EGF; amphiregulin; TGF-α ; betacellulin; etc. EGFR protein plays a crucial role in signaling pathway in the regulation of cell proliferation; survival and differentiation. Binding of a ligand induces EGFR protein homo- or heterodimerization; the subsequent tyrosine autophosphorylation and initiates various down stream pathways (MAPK; PI3K\/PKB and STAT). In addition; EGFR signaling also has been shown to exert action on carcinogenesis and disease progression; and thus EGFR protein is proposed as a target for cancer therapy currently.\n\nActivity: Immobilized recombinant human EGF at 10 μg\/ml (100 μl\/well) can bind human EGFR with a linear range of 0.64-400 ng\/ml.\n\nSequence: Met 1-Gly 645\n\nPurity: \u0026gt; 97 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4.\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 95 kDa\n\nObserved MW: 130-140 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104331563187,"sku":"PKSH031995-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_7913dfce-833f-43d4-aa70-c13476cd28a2.png?v=1709294504","url":"https:\/\/afsbio.com\/products\/recombinant-human-egfr-erbb1-protein-fc-tagactive-pksh031995","provider":"AFSBio Inc.","version":"1.0","type":"link"}