{"product_id":"recombinant-human-endoglin-cd105-protein-his-trx-tag-pksh032379","title":"Recombinant Human Endoglin\/CD105 Protein (His\u0026Trx Tag) - PKSH032379","description":"\u003cp\u003eRecombinant Human Endoglin\/CD105 Protein (His\u0026amp;Trx Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032379-10, PKSH032379-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Endoglin; CD105\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Endoglin; END; CD105; ENG; HHT1; ORW1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P17813\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-Trx-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P17813-1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Endoglin is a single-pass type I membrane protein which restricted to endothelial cells in all tissues except bone marrow. Endoglin as major glycoprotein of vascular endothelium, it has been found on endothelial cells, activated macrophages, fibroblasts, and smooth muscle cells. Furthermore, Homodimer forms a heteromeric complex with the signaling receptors for transforming growth factor-beta: TGFBR1 and\/or TGFBR2. It may have an important role in the binding of endothelial cells to integrins and\/or other RGD receptors. Defects in ENG are the cause of hereditary hemorrhagic telangiectasia type 1 (HHT1), which is an autosomal dominant multisystemic vascular dysplasia, characterized by recurrent epistaxis, muco-cutaneous telangiectases, gastro-intestinal hemorrhage, and pulmonary (PAVM), cerebral (CAVM) and hepatic arteriovenous malformations.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Glu26-Gln176\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33.6 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 34 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43149113393331,"sku":"PKSH032379-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43149113426099,"sku":"PKSH032379-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_fc7c34cf-4fc8-4cc8-abf0-4232117739b9.png?v=1710340869","url":"https:\/\/afsbio.com\/products\/recombinant-human-endoglin-cd105-protein-his-trx-tag-pksh032379","provider":"AFSBio Inc.","version":"1.0","type":"link"}