{"product_id":"recombinant-human-epo-receptor-epor-protein-fc-tagactive-pksh031462","title":"Recombinant Human EPO Receptor\/EPOR Protein (Fc Tag)(Active) - PKSH031462","description":"Recombinant Human EPO Receptor\/EPOR Protein (Fc Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031462-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: EPO Receptor; EPOR\n\nTarget Symptom: EPO-R\n\nResearch Area: Signal Transduction; Cardiovascular; immunology; Stem cells\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: Cell culture; ELISA\n\nFusion Tag: C-hFc\n\nAccession: NP_000112.1\n\nBackground: Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR\/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type â … single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.\n\nActivity: 1. Immobilized CD131 at 10 μg\/ml (100 μl\/well) can bind biotinylated recombinant human EPOR with a linear range of 0.16-4 μg\/ml. \n2. Measured by its ability to inhibit Epo­dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 1-4 ng\/ml in the presence of 0.1 U\/mL Recombinant Human EPO. \n\nSequence: Met-Pro 250\n\nPurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, 8% sucrose, 0.5% Tween-20, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 51.0 kDa\n\nObserved MW: 55-60 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104312754355,"sku":"PKSH031462-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ca7d011c-ea7a-47ac-8e5c-4b194ea75d8a.png?v=1709294078","url":"https:\/\/afsbio.com\/products\/recombinant-human-epo-receptor-epor-protein-fc-tagactive-pksh031462","provider":"AFSBio Inc.","version":"1.0","type":"link"}