{"product_id":"recombinant-human-erythropoietin-epo-protein-rp01690","title":"Recombinant Human Erythropoietin\/EPO Protein - RP01690","description":"\u003cp\u003eRecombinant Human Erythropoietin\/EPO Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01690-10, RP01690-20, RP01690-50, RP01690-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Erythropoietin\/EPO Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala28-Arg193) of human Erythropoietin\/EPO (Accession #NP_000790.2) fused with no additional amino acid.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: EP; DBAL; ECYT5; MVCD2; EPO; Erythropoietin\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P01588\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2056\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Erythropoietin (EPO) is the major glycoprotein hormone regulator of mammalian erythropoiesis, and is produced by kidney and liver in an oxygen-dependent manner. The biological effects of EPO are mediated by the specific erythropoietin receptor (EPOR\/EPO Receptor) on bone marrow erythroblasts, which transmits signals important for both proliferation and differentiation along the erythroid lineage. EPOR protein is a type a… single-transmembrane cytokine receptor, and belongs to the homodimerizing subclass which functions as ligand-induced or ligand-stabilized homodimers. EPOR signaling prevents neuronal death and ischemic injury. Recent studies have shown that EPO and EPOR protein may be involved in carcinogenesis, angiogenesis, and invasion.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured in a cell proliferation assay using TF-1 human erythroleukemic cells. The ED50 for this effect is 0.07-0.27 ng\/mL, corresponding to a specific activity of 3.70 × 10^6 ~1.43× 10^7 units\/mg.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: NO-tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: APPRLICDSRVLERYLLEAKEAENITTGCAEHCSLNENITVPDTKVNFYAWKRMEVGQQAVEVWQGLALLSEAVLRGQALLVNSSQPWEPLQLHVDKAVSGLRSLTTLLRALGAQKEAISPPDAASAAPLRTITADTFRKLFRVYSNFLRGKLKLYTGEACRTGDR\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198338982067,"sku":"RP01690-10","price":168.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198339014835,"sku":"RP01690-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198339047603,"sku":"RP01690-50","price":420.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198339080371,"sku":"RP01690-100","price":672.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_5b19f931-7ac8-4ac4-8b9f-af08d6bce77e.png?v=1766960776","url":"https:\/\/afsbio.com\/products\/recombinant-human-erythropoietin-epo-protein-rp01690","provider":"AFSBio Inc.","version":"1.0","type":"link"}