{"product_id":"recombinant-human-fbpase-1-fbp1-protein-e-coli-his-tag-pksh033276","title":"Recombinant Human FBPase 1\/FBP1 Protein (E. coli, His Tag) - PKSH033276","description":"\u003cp\u003eRecombinant Human FBPase 1\/FBP1 Protein (E. coli, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033276-10, PKSH033276-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: FBPase 1; FBP1\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Fructose-1; 6-Bisphosphatase 1; FBPase 1; D-Fructose-1; 6-Bisphosphate 1-Phosphohydrolase 1; FBP1; FBP\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Cancer; epigenetics and nuclear signal; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P09467\u003c\/p\u003e\n\n\u003cp\u003eAccession: P09467\u003c\/p\u003e\n\n\u003cp\u003eBackground: Fructose-1; 6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein; which catalyzes the hydrolysis of fructose 1; 6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state; or an inactive T-state. FBPase 1 deficiency is inherited as an autosomal recessive disorder mainly in the liver and causes life-threatening episodes of hypoglycemia and metabolic acidosis in newborn infants or young children. FBPase 1 coupled with phosphofructokinase (PFK) is involved in the metabolism of pancreatic islet cells.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala2-Gln338\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 85 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 200mM NaCl, 1mM DTT, 1mM EDTA, 20% Glycerol, pH 8.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 37.9 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 38 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113940320435,"sku":"PKSH033276-10","price":343.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113940353203,"sku":"PKSH033276-50","price":576.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_bd38ab85-4cfa-4744-97d1-83cf4ba85c55.png?v=1709548985","url":"https:\/\/afsbio.com\/products\/recombinant-human-fbpase-1-fbp1-protein-e-coli-his-tag-pksh033276","provider":"AFSBio Inc.","version":"1.0","type":"link"}