{"product_id":"recombinant-human-fc-gamma-riii-alpha-fcgr3a-cd16a-protein-rp00066","title":"Recombinant Human Fc-gamma RIII alpha\/FCGR3A\/CD16a Protein - RP00066","description":"\u003cp\u003eRecombinant Human Fc-gamma RIII alpha\/FCGR3A\/CD16a Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00066-10, RP00066-20, RP00066-50, RP00066-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Fc-gamma RIII alpha\/FCGR3A\/CD16a Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gly17-Gln208) of human Fc gamma RIIIA\/CD16a (Accession #NP_001121065.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20, FCGR3A, CD16, CD16A, FCG3, FCGR3, FCGRIII, FCR-10, FCRIII, FCRIIIA, IGFR3, IMD20, Fc fragment of IgG receptor IIIa\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P08637\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2214\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This protein is a receptor for the Fc portion of immunoglobulin G, and it is involved in the removal of antigen-antibody complexes from the circulation, as well as other other antibody-dependent responses. The protein is expressed on natural killer (NK) cells as an integral membrane glycoprotein anchored through a transmembrane peptide, whereas FCGR3B is expressed on polymorphonuclear neutrophils (PMN) where the receptor is anchored through a phosphatidylinositol (PI) linkage. Mutations in this gene have been linked to susceptibility to recurrent viral infections, susceptibility to systemic lupus erythematosus, and alloimmune neonatal neutropenia.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA. Immobilized Human FCGR3A at 1 μg\/mL (100 μL\/well) can bind FCGR3A Mouse mAb with a linear range of 0.13-6.1 ng\/mL.|2.Measured by its binding ability in a functional ELISA.Immobilized Human FCGR3A at 1 μg\/mL (100 μL\/well) can bind FCGR3A Mouse mAb with a linear range of 0.06-7.1 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: GMRTEDLPKAVVFLEPQWYRVLEKDSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAATVDDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVFKEEDPIHLRCHSWKNTALHKVTYLQNGKGRKYFHHNSDFYIPKATLKDSGSYFCRGLFGSKNVSSETVNITITQGLAVSTISSFFPPGYQ\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198296252595,"sku":"RP00066-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198296285363,"sku":"RP00066-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198296318131,"sku":"RP00066-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198296350899,"sku":"RP00066-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_fde534e9-6434-4213-8cad-cf522865ba41.png?v=1766960265","url":"https:\/\/afsbio.com\/products\/recombinant-human-fc-gamma-riii-alpha-fcgr3a-cd16a-protein-rp00066","provider":"AFSBio Inc.","version":"1.0","type":"link"}