{"product_id":"recombinant-human-fcrl2-fcrh2-irta4-protein-rp01984","title":"Recombinant Human FCRL2\/FCRH2 \/IRTA4 Protein - RP01984","description":"\u003cp\u003eRecombinant Human FCRL2\/FCRH2 \/IRTA4 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20ug, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01984-20, RP01984-50, RP01984-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human FCRL2\/FCRH2 \/IRTA4 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Leu20-Asp395) of Human FCRL2\/FCRH2 \/IRTA4 (Accession #NP_110391.2) fused with His at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: FCRL2, FCRH2, IFGP4, IRTA4, SPAP1, UNQ9236\/PRO31998, Fc receptor-like protein 2, FcR-like protein 2, FcRL2, Fc receptor homolog 2, FcRH2, IFGP family protein 4, Immunoglobulin receptor translocation-associated protein 4, SH2 domain-containing phosphatase anchor protein 1, CD307b\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q96LA5\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 79368\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: FCRL2\/FCRH2 \/IRTA4, belongs to the family of glycoprotein homologs of classical immunoglobulin (Ig) Fc receptors. In human, the type I transmembrane FCRL protein family contains from three to nine immunoglobulin-like domains. Mature human FcRH2 consists of a 382 amino acid (aa) extracellular domain (ECD) with four Ig-like C2-set domains, a 21 aa transmembrane segment, and an 86 aa cytoplasmic domain with one ITAM-like, and two ITIM-like motifs. Alternate splicing of human FCRL2 may generate isoforms with N-terminal, internal, or C-terminal deletions. The gene for FcRH2 maps to the human Iq21-23 locus which is a hotspot for chromosomal translocation events associated with B cell malignancies. Although there are several Fc receptor-like genes in the mouse, none of these is a clear ortholog to human FCRL2. FCRL proteins are differentially expressed among B cells. FCRL2 is preferentially expressed on naïve and CD27+ memory B cells within the spleen, lymph nodes, tonsils, and peripheral blood. It is also expressed on most B cells in B cell chronic lymphocytic leukemia (B-CLL) patients. FCRL2 upregulation is associated with mutation of the immunoglobulin heavy chain variable (IGHV) and less aggressive forms of B-CLL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LTLVAPSSVFEGDSIVLKCQGEQNWKIQKMAYHKDNKELSVFKKFSDFLIQSAVLSDSGNYFCSTKGQLFLWDKTSNIVKIKVQELFQRPVLTASSFQPIEGGPVSLKCETRLSPQRLDVQLQFCFFRENQVLGSGWSSSPELQISAVWSEDTGSYWCKAETVTHRIRKQSLQSQIHVQRIPISNVSLEIRAPGGQVTEGQKLILLCSVAGGTGNVTFSWYREATGTSMGKKTQRSLSAELEIPAVKESDAGKYYCRADNGHVPIQSKVVNIPVRIPVSRPVLTLRSPGAQAAVGDLLELHCEALRGSPPILYQFYHEDVTLGNSSAPSGGGASFNLSLTAEHSGNYSCEANNGLGAQCSEAVPVSISGPDGYRRD\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"20ug","offer_id":45198378664115,"sku":"RP01984-20","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198378696883,"sku":"RP01984-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198378729651,"sku":"RP01984-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_3d4df3d3-1888-4481-b639-c0b37b600973.png?v=1766961454","url":"https:\/\/afsbio.com\/products\/recombinant-human-fcrl2-fcrh2-irta4-protein-rp01984","provider":"AFSBio Inc.","version":"1.0","type":"link"}