{"product_id":"recombinant-human-fgf-19-fgf9-protein-his-tagactive-pksh032436","title":"Recombinant Human FGF-19\/FGF9 Protein (His Tag)(Active) - PKSH032436","description":"\u003cp\u003eRecombinant Human FGF-19\/FGF9 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032436-20, PKSH032436-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: FGF-19; FGF9\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Fibroblast growth factor 19; FGF-19; FGF19\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Neuroscience; Cancer; Stem cells\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O95750\u003c\/p\u003e\n\n\u003cp\u003eAccession: O95750\u003c\/p\u003e\n\n\u003cp\u003eBackground: Fibroblast growth factor 19 (FGF19) is a secreted protein which belongs to the FGFs family. FGF19 is expressed in fetal brain, cartilage, retina, and adult gall bladder. FGFs modulate cellular activity via at least 5 distinct subfamilies of high-affinity FGF receptors (FGFRs): FGFR-1, -2, -3, and -4, all with intrinsic tyrosine kinase activity. FGFRs can be important for regulation of glucose and lipid homeostasis. FGF19 has important roles as a hormone produced in the ileum in response to bile acid absorption. It has been shown to cause resistance to diet-induced obesity and insulin desensitization and to improve insulin, glucose, and lipid profiles in diabetic rodents. FGF19 can be considered as a regulator of energy expenditure.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human FGF-19-His at 2μg\/ml(100 μl\/well) can bind Human FGFR3-Fc(Cat: PKSH033678). The ED50 of Human FGF-19-His is 3. 1135 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Phe27-Lys216\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 23.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 24 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43118139080883,"sku":"PKSH032436-20","price":348.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43118139113651,"sku":"PKSH032436-100","price":1034.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_bc1b7ca5-fc31-4254-b317-f7f28a94190c.png?v=1709636915","url":"https:\/\/afsbio.com\/products\/recombinant-human-fgf-19-fgf9-protein-his-tagactive-pksh032436","provider":"AFSBio Inc.","version":"1.0","type":"link"}