{"product_id":"recombinant-human-fgfr-4-cd334-protein-rp00130","title":"Recombinant Human FGFR-4\/CD334 Protein - RP00130","description":"\u003cp\u003eRecombinant Human FGFR-4\/CD334 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00130-10, RP00130-20, RP00130-50, RP00130-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human FGFR-4\/CD334 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Leu22-Asp369) of human FGFR4\/FGF Receptor 4 (Accession #NP_998812.1) fused with an Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: CD334, JTK2, TKF, FGFR4, JTK2, TKF\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P22455\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2264\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: The protein is a member of the family of carcinoembryonic antigen-related cell adhesion molecules (CEACAMs), which are used by several bacterial pathogens to bind and invade host cells. The encoded transmembrane protein directs phagocytosis of several bacterial species that is dependent on the small GTPase Rac. It is thought to serve an important role in controlling human-specific pathogens by the innate immune system. Alternatively spliced transcript variants have been described.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA. Immobilized recombinant human FGF2 at 1 μg\/mL (100 μL\/well) can bind recombinant human FGFR4 with a linear range of 30-125 ng\/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized recombinant human FGFR4 at 5 μg\/mL (100 μL\/well) can bind recombinant human FGF12 with a linear range of 35-100 ng\/mL. 3.Measured by its ability to inhibit FGF-acidic dependent proliferation of Balb\/c 3T3 mouse fibroblasts. The ED50 for this effect is typically 0.03-0.12 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: LEASEEVELEPCLAPSLEQQEQELTVALGQPVRLCCGRAERGGHWYKEGSRLAPAGRVRGWRGRLEIASFLPEDAGRYLCLARGSMIVLQNLTLITGDSLTSSNDDEDPKSHRDPSNRHSYPQQAPYWTHPQRMEKKLHAVPAGNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTCLVENAVGSIRYNYLLDVLERSPHRPILQAGLPANTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEVEVLYLRNVSAEDAGEYTCLAGNSIGLSYQSAWLTVLPEEDPTWTAAAPEARYTD\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198300610739,"sku":"RP00130-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198300643507,"sku":"RP00130-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198300676275,"sku":"RP00130-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198300709043,"sku":"RP00130-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_73315e2e-bcab-4924-9596-b5d5ce81abdc.png?v=1766960322","url":"https:\/\/afsbio.com\/products\/recombinant-human-fgfr-4-cd334-protein-rp00130","provider":"AFSBio Inc.","version":"1.0","type":"link"}