{"product_id":"recombinant-human-frataxin-fxn-protein-his-tag-pdmh100050","title":"Recombinant Human Frataxin\/FXN protein (His tag) - PDMH100050","description":"\u003cp\u003eRecombinant Human Frataxin\/FXN protein (His tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 20μg, 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDMH100050-20, PDMH100050-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Frataxin; FXN\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Frataxin; mitochondrial; Friedreich ataxia protein; FXN; FRDA; X25; Frataxin intermediate form\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q16595\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q16595\u003c\/p\u003e\n\n\u003cp\u003eBackground: Frataxin intermediate form can cleave by mitochondrial processing peptidase(MPP) to the mature frataxin. Frataxin is a nuclear-encoded mitochondrial protein highly conserved in prokaryotes and eukaryotes. Its deficiency was initially described as the phenotype of Friedreich's ataxia, an autosomal recessive disease in humans. Although several functions have been described for frataxin, that is, involvement in Fe-S cluster and heme synthesis, energy conversion and oxidative phosphorylation, iron handling and response to oxidative damage, its precise function remains unclear. Although there is a general consensus on the participation of frataxin in the maintenance of cellular iron homeostasis and in iron metabolism, this protein may have other specific functions in different tissues and organisms.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Leu42-Ala210\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 18.48 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 21 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"20μg","offer_id":43149104775347,"sku":"PDMH100050-20","price":264.6,"currency_code":"CAD","in_stock":true},{"title":"100μg","offer_id":43149104808115,"sku":"PDMH100050-100","price":418.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_8fc87e7a-ff75-41d9-98f6-f8be221ffb80.png?v=1710340731","url":"https:\/\/afsbio.com\/products\/recombinant-human-frataxin-fxn-protein-his-tag-pdmh100050","provider":"AFSBio Inc.","version":"1.0","type":"link"}