{"product_id":"recombinant-human-frizzled-2-fzd2-protein-rp01422","title":"Recombinant Human Frizzled-2\/FZD2 Protein - RP01422","description":"\u003cp\u003eRecombinant Human Frizzled-2\/FZD2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01422-10, RP01422-50, RP01422-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Frizzled-2\/FZD2 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln24-Leu163) of human Frizzled-2\/FZD2 (Accession #NP_001457.1) fused with a Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: Fz2, fz-2, fzE2, hFz2, OMOD2, FZD2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q14332\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2535\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz\/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and\/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt\/beta-catenin signaling pathway.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QFHGEKGISIPDHGFCQPISIPLCTDIAYNQTIMPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLEQAIPPCRSICERARQGCEALMNKFGFQWPERLRCEHFPRHGAEQICVGQNHSEDGAPAL\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198372634803,"sku":"RP01422-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198372667571,"sku":"RP01422-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198372700339,"sku":"RP01422-100","price":448.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_a7619332-4a49-42ab-8e6a-cf221219a6d6.png?v=1766961352","url":"https:\/\/afsbio.com\/products\/recombinant-human-frizzled-2-fzd2-protein-rp01422","provider":"AFSBio Inc.","version":"1.0","type":"link"}