{"product_id":"recombinant-human-frizzled-7-fzd7-protein-rp00204","title":"Recombinant Human Frizzled-7\/FZD7 Protein - RP00204","description":"\u003cp\u003eRecombinant Human Frizzled-7\/FZD7 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00204-10, RP00204-20, RP00204-50, RP00204-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Frizzled-7\/FZD7 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gln33-Leu185) of human Frizzled-7 (Accession #NP_003498.1) fused with an Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: FZD7, FzE3\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O75084\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8324\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Frizzled-7 is a member of the Frizzled family of unconventional G-protein-coupled glycoprotein receptors for the Wnt signaling pathway. During development, Frizzled-7 is expressed during gastrulation and in the fetal gut, kidney and lung where it is thought to influence tissue morphogenesis via non-canonical signaling pathways. In the adult, Frizzled-7 is expressed in skeletal muscle, especially in satellite cells that mediate muscle regeneration in response to Wnt-7a. It is expressed in embryonic stem cells (ES), contributing to self-renewal signaling. Frizzled-7 expression may downregulate APC function and enhance beta-catenin-mediated signals in poorly differentiated human esophageal carcinomas.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA. Immobilized Human Glypican-3 Protein at 5 μg\/mL (100 μL\/well) can bind Human FZD7 with a linear range of 4.88-935.5 ng\/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized Human Glypican-3 Protein at 5 μg\/mL (100 μL\/well) can bind Human FZD7 with a linear range of 4.88-520.4 ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QPYHGEKGISVPDHGFCQPISIPLCTDIAYNQTILPNLLGHTNQEDAGLEVHQFYPLVKVQCSPELRFFLCSMYAPVCTVLDQAIPPCRSLCERARQGCEALMNKFGFQWPERLRCENFPVHGAGEICVGQNTSDGSGGPGGGPTAYPTAPYL\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198299300019,"sku":"RP00204-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198299332787,"sku":"RP00204-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198299365555,"sku":"RP00204-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198299398323,"sku":"RP00204-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_237e6f99-69a7-4bf9-ba90-e9a2419d0966.png?v=1766960301","url":"https:\/\/afsbio.com\/products\/recombinant-human-frizzled-7-fzd7-protein-rp00204","provider":"AFSBio Inc.","version":"1.0","type":"link"}