{"product_id":"recombinant-human-fumarase-fh-protein-pksh032462","title":"Recombinant Human Fumarase\/FH Protein - PKSH032462","description":"\u003cp\u003eRecombinant Human Fumarase\/FH Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032462-10, PKSH032462-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Fumarase; FH\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Fumarate Hydratase Mitochondrial; Fumarase; FH; FMRD; HLRCC; LRCC; MCL; MCUL1\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P07954\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: None\u003c\/p\u003e\n\n\u003cp\u003eAccession: P07954\u003c\/p\u003e\n\n\u003cp\u003eBackground: Fumarase is an enzyme that catalyze the reversible hydration\/dehydration of fumarate to S-malate and is involved in the tricarboxylic acid or Krebs cycle. Fumarase exists in both form, cytosolic formand N-terminal extend mitochondrial form. The N-terminal extended form is targeted to the mitochondrion, where the removal of the extension is the same form as in the cytoplasm. Fumarase is thought to act as a tumor suppressor, which deficiency can lead to progressive encephalopathy, cerebral atrophy and development delay.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ala45-Lys510\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris, pH 8.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 50.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 45 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43092782678195,"sku":"PKSH032462-10","price":312.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43092782710963,"sku":"PKSH032462-50","price":830.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_79c942ee-675b-43b9-a175-a108ab584e27.png?v=1709119821","url":"https:\/\/afsbio.com\/products\/recombinant-human-fumarase-fh-protein-pksh032462","provider":"AFSBio Inc.","version":"1.0","type":"link"}