{"product_id":"recombinant-human-gaba-protein-his-fctag-pksh032465","title":"Recombinant Human GABA Protein (His \u0026 FcTag) - PKSH032465","description":"\u003cp\u003eRecombinant Human GABA Protein (His \u0026amp; FcTag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032465-10, PKSH032465-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GABA\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: GABA(A) Receptor-Associated Protein; GABARAP Protein; HCG1987397 Isoform CRA_b; GABARAP\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q6IAW1\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His; C-Fc\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q6IAW1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Gamma-Aminobutyric Acid Receptor-Associated Protein (GABARAP) is a ligand-gated chloride channel protein that mediates inhibitory neurotransmission and belongs to the MAP1 LC3 family. GABARAP is highly positively charged in its N-terminus and shares sequence similarity with light chain-3 of microtubule-associated proteins 1A and 1B. GABARAP clusters neurotransmitter receptors by mediating interaction with the cytoskeleton. Autophagy is the process by which cells recycle cytoplasm and dispose of excess or defective organelles. This process is suggested to be involved development; differentiation; growth regulation and tissue remodeling in multicellular organisms. An important inhibitory neurotransmitter; GABA; acts on GABA receptors that are ubiquitously expressed in the CNS. GABARAP has been shown to play a important role in intracellular transport of GABA(A) receptors and its interaction with the cytoskeleton.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Gln116\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 20% glycerol, pH7.0.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 43.2 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 50 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43149113983155,"sku":"PKSH032465-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43149114015923,"sku":"PKSH032465-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_667184ee-5816-4331-b1fc-4bdc90e12a52.png?v=1710340883","url":"https:\/\/afsbio.com\/products\/recombinant-human-gaba-protein-his-fctag-pksh032465","provider":"AFSBio Inc.","version":"1.0","type":"link"}