{"product_id":"recombinant-human-galectin-1-lgals1-protein-rp00007","title":"Recombinant Human Galectin-1\/LGALS1 Protein - RP00007","description":"\u003cp\u003eRecombinant Human Galectin-1\/LGALS1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00007-10, RP00007-20, RP00007-50, RP00007-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Galectin-1\/LGALS1 Protein is produced by E. coli expression system. The target protein is expressed with sequence (Ala2-Asp135) of human Galectin-1 (Accession #NP_002296.1).\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: GAL1, GBP, LGALS1, GAL1, galectin-1, GBP, Galectin 1\/LGALS1\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P09382\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3956\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Galectin-1, also known as LGALS1 (lectin, galactoside-binding, soluble 1), is a 135 amino acid (aa), 14 kDa, pleiotropic, Non-glycosylated, monomeric or homodimeric carbohydrate-binding protein of the prototype galectin family. Galectins lack a classical signal peptide and can be localized to the cytosolic compartments, or secreted by non-classical pathways. Secreted Galectin-1 has immunosuppressive and anti-inflammatory properties and suppresses acute and chronic inflammation and autoimmunity. It contributes to negative selection of developing T cells, immunosuppression by regulatory T cells, resolution of the inflammatory response, and inhibition of immune cell migration, inflammatory cytokine production, and mast cell degranulation. Galectin-1 contributes to different steps of tumour progression including cell adhesion, migration and tumour-immune escape, suggesting that blockade of galectin-1 might result in therapeutic benefits in cancer. Several potential glycoprotein ligands for galectin-1 have been identified, including lysosome-associated membrane glycoproteins and fibronectin, laminin, as well as T-cell glycoproteins CD43 and CD45. Evidence points to Gal-1 and its ligands as one of the master regulators of such immune responses as T-cell homeostasis and survival, T-cell immune disorders, inflammation and allergies as well as host-pathogen interactions.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by its ability to agglutinate mouse red blood cells. The ED50 for this effect is 0.5-3 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: No tag\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: ACGLVASNLNLKPGECLRVRGEVAPDAKSFVLNLGKDSNNLCLHFNPRFNAHGDANTIVCNSKDGGAWGTEQREAVFPFQPGSVAEVCITFDQANLTVKLPDGYEFKFPNRLNLEAINYMAADGDFKIKCVAFD\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198291108019,"sku":"RP00007-10","price":182.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198291140787,"sku":"RP00007-20","price":252.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198291173555,"sku":"RP00007-50","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198291206323,"sku":"RP00007-100","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_bd8865f4-55da-431e-8733-96a0a646192f.png?v=1766960200","url":"https:\/\/afsbio.com\/products\/recombinant-human-galectin-1-lgals1-protein-rp00007","provider":"AFSBio Inc.","version":"1.0","type":"link"}