{"product_id":"recombinant-human-gamma-glutamyl-hydrolase-ggh-protein-rp01957","title":"Recombinant Human Gamma-glutamyl hydrolase\/GGH Protein - RP01957","description":"\u003cp\u003eRecombinant Human Gamma-glutamyl hydrolase\/GGH Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP01957-10, RP01957-20, RP01957-50, RP01957-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human Gamma-glutamyl hydrolase\/GGH Protein is produced by E. coli expression system. The target protein is expressed with sequence (Arg25-Asp318) of Human Gamma-glutamyl hydrolase\/GGH (Accession #NP_003869.1) fused with a His tag at the N-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: GGH, Gamma-glutamyl hydrolase, EC:3.4.19.9, Conjugase, GH, Gamma-Glu-X carboxypeptidase\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q92820\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 8836\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Gamma-glutamyl hydrolase\/GGH regulates intracellular folates and antifolates such as methotrexate (MTX) for proper nucleotide biosynthesis and antifolate-induced cytotoxicity, respectively. GGH is a ubiquitously-expressed enzyme that regulates intracellular folate metabolism for cell proliferation, DNA synthesis, and repair. cytoplasmic GGH might play a relevant role in the development and progression of invasive breast cancer.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: N-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of 20mM HEPES, 150mM NaCl, 1mM TCEP, pH 8.0.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: RPHGDTAKKPIIGILMQKCRNKVMKNYGRYYIAASYVKYLESAGARVVPVRLDLTEKDYEILFKSINGILFPGGSVDLRRSDYAKVAKIFYNLSIQSFDDGDYFPVWGTCLGFEELSLLISGECLLTATDTVDVAMPLNFTGGQLHSRMFQNFPTELLLSLAVEPLTANFHKWSLSVKNFTMNEKLKKFFNVLTTNTDGKIEFISTMEGYKYPVYGVQWHPEKAPYEWKNLDGISHAPNAVKTAFYLAEFFVNEARKNNHHFKSESEEEKALIYQFSPIYTGNISSFQQCYIFD\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198278754483,"sku":"RP01957-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198278787251,"sku":"RP01957-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198278820019,"sku":"RP01957-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198278852787,"sku":"RP01957-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_8097852b-6095-4d0e-99fc-9dd3fe1b04e5.png?v=1766960052","url":"https:\/\/afsbio.com\/products\/recombinant-human-gamma-glutamyl-hydrolase-ggh-protein-rp01957","provider":"AFSBio Inc.","version":"1.0","type":"link"}