{"product_id":"recombinant-human-gamt-protein-his-tag-pksh032515","title":"Recombinant Human GAMT Protein (His Tag) - PKSH032515","description":"\u003cp\u003eRecombinant Human GAMT Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032515-10, PKSH032515-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GAMT\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Guanidinoacetate N-methyltransferase; GAMT; PIG2; TP53I2\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q14353\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; metabolism;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-His \u0026amp; C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q14353\u003c\/p\u003e\n\n\u003cp\u003eBackground: GAMT is a methyltransferase which belongs to the class I-like SAM-binding methyltransferase superfamily. It contains one RMT2 (arginine N-methyltransferase 2-like) domain and is expressed in liver. GAMT converts guanidoacetate to creatine, using S-adenosylmethionine as the methyl donor. Defects in GAMT are the cause of guanidinoacetate methyltransferase deficiency, which is an autosomal recessive disorder characterized by developmental delay\/regression, mental retardation, severe disturbance of expressive and cognitive speech, intractable seizures and movement disturbances, severe depletion of creatine\/phosphocreatine in the brain, and accumulation of guanidinoacetic acid in brain and body fluids.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Gly236\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM Tris-HCl, 1mMDTT, pH 8.0 .\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 29.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 30 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068840902835,"sku":"PKSH032515-10","price":368.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068840935603,"sku":"PKSH032515-50","price":684.6,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_29502e07-1a69-4b60-bf1f-ffaa5b27b19f.png?v=1708598093","url":"https:\/\/afsbio.com\/products\/recombinant-human-gamt-protein-his-tag-pksh032515","provider":"AFSBio Inc.","version":"1.0","type":"link"}