{"product_id":"recombinant-human-gankyrin-psdm10-protein-pksh032479","title":"Recombinant Human Gankyrin\/PSDM10 Protein - PKSH032479","description":"\u003cp\u003eRecombinant Human Gankyrin\/PSDM10 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032479-10, PKSH032479-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Gankyrin; PSDM10\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: 26S Proteasome Non-ATPase Regulatory Subunit 10; 26S Proteasome Regulatory Subunit p28; Gankyrin; p28(GANK); PSMD10\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: O75832\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cell biology; Cancer\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: None\u003c\/p\u003e\n\n\u003cp\u003eAccession: O75832\u003c\/p\u003e\n\n\u003cp\u003eBackground: Gankyrin is a multicatalytic proteinase oncoprotein consists of 7 ankyrin repeats. Gankyrin overexpressed in most hepatocellular carcinomas. Gankyrin is involved in theregulation of the phosphorylation of the retinoblastoma protein by CDK4 to enhance the ubiquitinylation of p53 by MDM2. Gankyrin is also involved in progression of esophageal squamous cell carcinoma. Gankyrin plays an oncogenic role especially in early stages of human epatocarcinogenesis.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Gly226\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 10% Glycerol, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 24.4 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 26 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43092785660083,"sku":"PKSH032479-10","price":385.0,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43092785692851,"sku":"PKSH032479-50","price":735.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_ff45b976-c27d-47c6-a4ea-b908ca713133.png?v=1709119856","url":"https:\/\/afsbio.com\/products\/recombinant-human-gankyrin-psdm10-protein-pksh032479","provider":"AFSBio Inc.","version":"1.0","type":"link"}