{"product_id":"recombinant-human-gdnfr-alpha-2-gfra2-protein-rp00199","title":"Recombinant Human GDNFR-alpha-2\/GFRA2 Protein - RP00199","description":"\u003cp\u003eRecombinant Human GDNFR-alpha-2\/GFRA2 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00199-10, RP00199-20, RP00199-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human GDNFR-alpha-2\/GFRA2 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Ser22-Ser441) of human GFRA2\/GFRα2\/GDNFRB (Accession #NP_001486.4) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: GFRA2, GDNFRB, NRTNR-ALPHA, NTNRA, RETL2, TRNR2\u003c\/p\u003e\n\n\u003cp\u003eSWISS: O00451\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2675\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. The protein encoded by this gene is a member of the GDNF receptor family. It is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases.\u003c\/p\u003e \n\n\u003cp\u003eBio-Activity: Measured by its binding ability in a functional ELISA. Immobilized recombinant Human Neurturin at 5 μg\/mL (100 μL\/well) can bind recombinant Human GFRA2, the EC50 of Human GFRA2 is 1.82 μg\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: SPSSLQGPELHGWRPPVDCVRANELCAAESNCSSRYRTLRQCLAGRDRNTMLANKECQAALEVLQESPLYDCRCKRGMKKELQCLQIYWSIHLGLTEGEEFYEASPYEPVTSRLSDIFRLASIFSGTGADPVVSAKSNHCLDAAKACNLNDNCKKLRSSYISICNREISPTERCNRRKCHKALRQFFDRVPSEYTYRMLFCSCQDQACAERRRQTILPSCSYEDKEKPNCLDLRGVCRTDHLCRSRLADFHANCRASYQTVTSCPADNYQACLGSYAGMIGFDMTPNYVDSSPTGIVVSPWCSCRGSGNMEEECEKFLRDFTENPCLRNAIQAFGNGTDVNVSPKGPSFQATQAPRVEKTPSLPDDLSDSTSLGTSVITTCTSVQEQGLKANNSKELSMCFTELTTNIIPGSNKVIKPNS\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198371750067,"sku":"RP00199-10","price":154.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198371782835,"sku":"RP00199-20","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198371815603,"sku":"RP00199-100","price":280.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_26d9d98c-cb10-420a-b7c8-c576fc29468d.png?v=1766961338","url":"https:\/\/afsbio.com\/products\/recombinant-human-gdnfr-alpha-2-gfra2-protein-rp00199","provider":"AFSBio Inc.","version":"1.0","type":"link"}