{"product_id":"recombinant-human-gfer-alr-protein-rp02175","title":"Recombinant Human GFER\/ALR Protein - RP02175","description":"\u003cp\u003eRecombinant Human GFER\/ALR Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 50ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: RP02175-10, RP02175-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human GFER\/ALR Protein is produced by E.coli expression system. The target protein is expressed with sequence (Met1-Asp125) of human GFER (Accession #P55789) fused with a 6xHis tag at the N-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: GFER, ALR, ERV1, HERV1, HPO, HPO1, HPO2, HSS\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P55789\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 2671\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1\/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4\/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4\/MIA40 forms a transient intermolecular disulfide bridge with GFER\/ERV1, resulting in regeneration of the essential disulfide bonds in CHCHD4\/MIA40, while GFER\/ERV1 becomes re- oxidized by donating electrons to cytochrome c or molecular oxygen. Isoform 2 may act as an autocrine hepatotrophic growth factor promoting liver regeneration. GFER could also induce the expression of S- adenosylmethionine decarboxyl-ase and ornithine decarboxylases (ODC). S-adenosylmethionine decarboxyl-ase and ornithine decarboxylases play an important role in the synthesis of polyamines.\u003c\/p\u003e\n\n\u003cp\u003eSource: E. coli\u003c\/p\u003e\n\n\u003cp\u003eTag: N-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198352285875,"sku":"RP02175-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198352318643,"sku":"RP02175-50","price":420.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_3df894b4-9099-4e0e-8b36-bc13e53970c7.png?v=1766960961","url":"https:\/\/afsbio.com\/products\/recombinant-human-gfer-alr-protein-rp02175","provider":"AFSBio Inc.","version":"1.0","type":"link"}