{"product_id":"recombinant-human-glut6-slc2a6-protein-gst-his-tag-pdeh100310","title":"Recombinant Human GLUT6\/SLC2A6 protein (GST,His tag) - PDEH100310","description":"\u003cp\u003eRecombinant Human GLUT6\/SLC2A6 protein (GST,His tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PDEH100310-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: GLUT6; SLC2A6\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Solute carrier family 2; facilitated glucose transporter member 6; SLC2A6; Glucose transporter type 6; GLUT6\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9UGQ3\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Metabolism; Signal Transduction\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-GST \u0026amp; C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9UGQ3-1\u003c\/p\u003e\n\n\u003cp\u003eBackground: GLUT6 as a functionally uncharacterized transporter that putatively works in inflammatory responses. Inflammatory stimuli increase GLUT6 expression level, although GLUT6-knockout mice exhibit a subtle phenotype to lipopolysaccharide administration. Metabolomics and in vitro analyses show that GLUT6 functions as a glycolysis modulator in inflammatory macrophages. GLUT6 does not mediate glucose uptake and is localized on lysosomal membranes. We conclude that GLUT6 is a lysosomal transporter that is regulated by inflammatory stimuli and modulates inflammatory responses by affecting the metabolic shift in macrophages.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Asn 216-Thr 289\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile PBS, pH 7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: Please contact us for more information.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 33.03 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 35 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"100μg","offer_id":43083544756403,"sku":"PDEH100310-100","price":165.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_87e4fb2c-f1dc-4906-8200-d40ff05bf2c7.png?v=1708944430","url":"https:\/\/afsbio.com\/products\/recombinant-human-glut6-slc2a6-protein-gst-his-tag-pdeh100310","provider":"AFSBio Inc.","version":"1.0","type":"link"}