{"product_id":"recombinant-human-glypican-5-gpc5-protein-his-tagactive-pksh031890","title":"Recombinant Human Glypican 5\/GPC5 Protein (His Tag)(Active) - PKSH031890","description":"\u003cp\u003eRecombinant Human Glypican 5\/GPC5 Protein (His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSize: 100μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Number: PKSH031890-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Glypican 5; GPC5\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: GPC5; bA93M14.1; glypican proteoglycan 5; glypican-5\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: Baculovirus-Insect Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-His\u003c\/p\u003e\n\n\u003cp\u003eAccession: NP_004457.1\u003c\/p\u003e\n\n\u003cp\u003eBackground: Glypican-5 (GPC5), is a cell membrane protein which belongs to the glypican family. The glypicans compose a family of glycosylphosphatidylinositol-anchored heparan sulfate proteoglycans that may play a role in the control of cell division and growth regulation. So far, six members (Glypican-1\/GPC1, Glypican-2\/GPC2, Glypican-3\/GPC3, Glypican-4\/GPC4, Glypican-5\/GPC5, Glypican-6\/GPC6) of this family are known in vertebrates. In adult, Glypican-5 is primarily expressed in the brain. It is also detected in fetal brain, lung and liver. Glypican-5 enhances the intracellular signaling of FGF2 and HGF. It alters the cellular distribution of FGF2. The properties of Glypican-5 make it an attractive target for therapeutic intervention in rhabdomyosarcomas and other tumors that amplify and\/or overexpress its gene. Glypican-5 is over-expressed in lymphoma cell lines that had shown amplification. It is a likely target for amplification, and that over-expression of GPC5 may contribute to development and\/or progression of lymphomas and other tumors.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized human GPC5 at 5 μg\/ml (100 μl\/well) can bind human bFGF with a linear ranger of 0.156-2. 5 ng\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Thr 554\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 92 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from sterile 50mM Tris, 100mM NaCl, pH 8.0\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 60.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 60.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104329597107,"sku":"PKSH031890-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_e8cd1e40-5e08-461c-a524-3459164793cd.png?v=1709294452","url":"https:\/\/afsbio.com\/products\/recombinant-human-glypican-5-gpc5-protein-his-tagactive-pksh031890","provider":"AFSBio Inc.","version":"1.0","type":"link"}