{"product_id":"recombinant-human-haptoglobin-zonulin-protein-aa-19-160-aa-162-406-his-tag-pksh032517","title":"Recombinant Human Haptoglobin\/Zonulin Protein (aa 19-160\u0026aa 162-406, His Tag) - PKSH032517","description":"\u003cp\u003eRecombinant Human Haptoglobin\/Zonulin Protein (aa 19-160\u0026amp;aa 162-406, His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032517-10, PKSH032517-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: Haptoglobin; Zonulin\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Haptoglobin; Zonulin; HP\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P00738\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Cardiovascular\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P00738\u003c\/p\u003e\n\n\u003cp\u003eBackground: Haptoglobin(HP) is a secreted protein which is a member of the peptidase S1 family of serine proteases. As a result of hemolysis; hemoglobin is found to accumulate in the kidney and is secreted in the urine. Haptoglobin captures; and combines with free plasma hemoglobin to allow hepatic recycling of heme iron and to prevent kidney damage. Haptoglobin also acts as an Antimicrobial; Antioxidant has antibacterial activity and plays a role in modulating many aspects of the acute phase response. Hemoglobin\/haptoglobin complexes are rapidely cleared by the macrophage CD163 scavenger receptor expressed on the surface of liver Kupfer cells through an endocytic lysosomal degradation pathway. Uncleaved haptoglogin; also known as zonulin; plays a role in intestinal permeability; allowing intercellular tight junction disassembly; and controlling the equilibrium between tolerance and immunity to non-self antigens.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Val19-Gln160\u0026amp;Ile162-Asn406\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 15.9\u0026amp;28.3\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 16\u0026amp;40-75 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43068841164979,"sku":"PKSH032517-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43068841197747,"sku":"PKSH032517-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_6e0a8fa1-1151-43c6-a3f0-f9a7ac082953.png?v=1708598097","url":"https:\/\/afsbio.com\/products\/recombinant-human-haptoglobin-zonulin-protein-aa-19-160-aa-162-406-his-tag-pksh032517","provider":"AFSBio Inc.","version":"1.0","type":"link"}