{"product_id":"recombinant-human-hip2-ube2k-protein-his-tag-sumo-tag-pksh033186","title":"Recombinant Human HIP2\/UBE2K Protein (His Tag, SUMO Tag) - PKSH033186","description":"\u003cp\u003eRecombinant Human HIP2\/UBE2K Protein (His Tag, SUMO Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033186-10, PKSH033186-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: HIP2; UBE2K\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Ubiquitin-Conjugating Enzyme E2 K; Huntingtin-Interacting Protein 2; HIP-2; Ubiquitin Carrier Protein; Ubiquitin-Conjugating Enzyme E2-25 kDa; Ubiquitin-Conjugating Enzyme E2(25K); Ubiquitin-Conjugating Enzyme E2-25K; Ubiquitin-Protein Ligase; UBE2K; HIP2; LIG\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Cell biology; Neuroscience; epigenetics and nuclear signal\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: N-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P61086\u003c\/p\u003e\n\n\u003cp\u003eAccession: P61086\u003c\/p\u003e\n\n\u003cp\u003eBackground: Ubiquitin-Conjugating Enzyme E2 K (UBE2K) belongs to the E2 Ubiquitin-Conjugating Enzyme family. UBE2K is highly expressed in the brain; with highest levels found in cortex and striatum; and at lower levels in cerebellum and brainstem. UBE2K may mediate foam cell formation by the suppression of apoptosis of lipid-bearing macrophages through ubiquitination and subsequence degradation of p53\/TP53. UBE2K is associated with the selective degradation of short-lived and abnormal proteins; such as the endoplasmic reticulum-associated degradation (ERAD) of misfolded lumenal proteins. In addition; UBE2K is involved in Alzheimer's disease; Huntington's disease and antigen processing through its interaction with huntingtin; and MHC-heavy chain proteins.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met 1-Asn200\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Supplied as a 0.2 μm filtered solution of 20mM PB; 150mM NaCl; pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Not Applicable\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 34.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 38 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at \u0026lt; -20°C, stable for 6 months. Please minimize freeze-thaw cycles.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as liquid. It is shipped at frozen temperature with blue ice\/gel packs. Upon receipt, store it immediately at \u0026lt; - 20°C.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113924034739,"sku":"PKSH033186-10","price":260.4,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113924067507,"sku":"PKSH033186-50","price":359.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_cb9f00c8-39d8-4b99-af25-0ab22789b574.png?v=1709548765","url":"https:\/\/afsbio.com\/products\/recombinant-human-hip2-ube2k-protein-his-tag-sumo-tag-pksh033186","provider":"AFSBio Inc.","version":"1.0","type":"link"}