{"product_id":"recombinant-human-hmgb1-protein-pksh033654","title":"Recombinant Human HMGB1 Protein - PKSH033654","description":"\u003cp\u003eRecombinant Human HMGB1 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033654-10, PKSH033654-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: HMGB1\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: High Mobility Group Protein B1; High Mobility Group Protein 1; HMG-1; HMGB1; HMG1\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: epigenetics and nuclear signal\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: E.coli\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: None\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P09429\u003c\/p\u003e\n\n\u003cp\u003eAccession: P09429\u003c\/p\u003e\n\n\u003cp\u003eBackground: High mobility group protein B1 is a member of the HMGB family consisting of three members; HMGB1; HMGB2 and HMGB3.It Contains 2 HMG box DNA-binding domains entitled box A and box B and It is a highly negative-charged C terminus. As a nuclear protein; HMGB1 stabilizes nucleosomes and allows bending of DNA that facilitates gene transcription which is essential for individual survival. Meanwhile; it is revealed that HMGB1 can also act as a cytokine extracellularlly and regulates monocyte; T cell; dendritic cell activities in inflammatory responses.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Met1-Phe89\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 50mMHepes; 500mMNaCl; 0.5mMDTT, pH7.9 .\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 10.5 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 14 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113979576499,"sku":"PKSH033654-10","price":180.6,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113979609267,"sku":"PKSH033654-50","price":525.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5d6e26f0-2155-40e8-b0df-7b25df47e92b.png?v=1709549551","url":"https:\/\/afsbio.com\/products\/recombinant-human-hmgb1-protein-pksh033654","provider":"AFSBio Inc.","version":"1.0","type":"link"}