{"product_id":"recombinant-human-icam-3-cd50-protein-rp00979","title":"Recombinant Human ICAM-3\/CD50 Protein - RP00979","description":"\u003cp\u003eRecombinant Human ICAM-3\/CD50 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20ug, 50ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00979-10, RP00979-20, RP00979-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human ICAM-3\/CD50 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Gln30-His485) of human CD50 (Accession #NP_002153.2) fused with an Fc, 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: ICAM3, CD50, CDW50, ICAM-R, ICAM3 \/ CD50\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P32942\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3385\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: This protein is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: Measured by the ability of the immobilized protein to support the adhesion of THP-1 cells. When cells are added to ICAM-3 coated plates (12.5 μg\/mL, 100 μL\/well),approximately \u0026gt;50% cells will adhere specifically after 60 minutes at 37 ℃.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-hFc\u0026amp;His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: QEFLLRVEPQNPVLSAGGSLFVNCSTDCPSSEKIALETSLSKELVASGMGWAAFNLSNVTGNSRILCSVYCNGSQITGSSNITVYRLPERVELAPLPPWQPVGQNFTLRCQVEDGSPRTSLTVVLLRWEEELSRQPAVEEPAEVTATVLASRDDHGAPFSCRTELDMQPQGLGLFVNTSAPRQLRTFVLPVTPPRLVAPRFLEVETSWPVDCTLDGLFPASEAQVYLALGDQMLNATVMNHGDTLTATATATARADQEGAREIVCNVTLGGERREARENLTVFSFLGPIVNLSEPTAHEGSTVTVSCMAGARVQVTLDGVPAAAPGQPAQLQLNATESDDGRSFFCSATLEVDGEFLHRNSSVQLRVLYGPKIDRATCPQHLKWKDKTRHVLQCQARGNPYPELRCLKEGSSREVPVGIPFFVNVTHNGTYQCQASSSRGKYTLVVVMDIEAGSSH\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198368407731,"sku":"RP00979-10","price":196.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198368440499,"sku":"RP00979-20","price":266.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198368473267,"sku":"RP00979-50","price":280.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_542bc19d-f528-49c4-a009-694cbbfe254d.png?v=1766961285","url":"https:\/\/afsbio.com\/products\/recombinant-human-icam-3-cd50-protein-rp00979","provider":"AFSBio Inc.","version":"1.0","type":"link"}