{"product_id":"recombinant-human-icos-ailim-protein-fc-tag-pksh033644","title":"Recombinant Human ICOS\/AILIM Protein (Fc Tag) - PKSH033644","description":"\u003cp\u003eRecombinant Human ICOS\/AILIM Protein (Fc Tag)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH033644-10, PKSH033644-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: ICOS; AILIM\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS;\u003c\/p\u003e \n\n\u003cp\u003eResearch Area: immunology\u003c\/p\u003e\n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-Fc\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q9Y6W8\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q9Y6W8\u003c\/p\u003e\n\n\u003cp\u003eBackground: Inducible T-cell costimulator, also known as activation-inducible lymphocyte immunomediatory molecule, CD278, AILIM, CVID1 and ICOS, belongs to the CD28 and CTLA4 cell surface receptor family.. ICOS contains one Ig-like V-type domain and exsits as a homodimer with disulfide-linked. ICOS is highly expressed on tonsillar T-cellsand can be induced by PMA and ionomycin, ICOS plays an important role in cell-cell signaling, immune responses, and regulation of cell proliferation. Defects in ICOS are the cause of immunodeficiency common variable type 1, which is a primary immunodeficiency characterized by antibody deficiency, hypogammaglobulinemia, recurrent bacterial infections and an inability to mount an antibody response to antige\u003c\/p\u003e\n\n\u003cp\u003eSequence: Glu21-Phe141\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 40.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 47 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43113979019443,"sku":"PKSH033644-10","price":163.8,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43113979052211,"sku":"PKSH033644-50","price":415.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_c8d78deb-e0cb-4c2d-a911-56b59e820fb9.png?v=1709549535","url":"https:\/\/afsbio.com\/products\/recombinant-human-icos-ailim-protein-fc-tag-pksh033644","provider":"AFSBio Inc.","version":"1.0","type":"link"}