{"product_id":"recombinant-human-icos-ailim-protein-his-fc-tagactive-pksh031664","title":"Recombinant Human ICOS\/AILIM Protein (His \u0026 Fc Tag)(Active) - PKSH031664","description":"Recombinant Human ICOS\/AILIM Protein (His \u0026amp; Fc Tag)(Active)\n\nSize: 100μg\n\nCatalogue Number: PKSH031664-100\n\nCitations, Manuals and MSDS Available upon request.\n\nAbbreviation: ICOS; AILIM\n\nTarget Symptom: Inducible T-cell costimulator; activation-inducible lymphocyte immunomediatory molecule; CD278; AILIM; CVID1; ICOS; \n\nResearch Area: immunology\n\nTarget Species: Human\n\nExpression Host: HEK293 Cells\n\nApplication: ELISA\n\nFusion Tag: C-His \u0026amp; Fc\n\nAccession: NP_036224.1\n\nBackground: Inducible costimulator (ICOS), also called AILIM (activiation-inducible lymphocyte immunomediatory molecule) is a cell-surface receptor, and belongs to the CD28 family of immune costimulatory receptors consisting of CD28, CTLA-4 and PD-1. The interaction of B7-H2\/ICOS plays a critical role in Th cell differentiation, T− B cell interactions which is essential for germinal center formation, and humoral immune responses, and as well as the production of cytokine IL-4. In addition, ICOS is more potent in the induction of IL-10 production, a cytokine important for suppressive function of T regulatory cells. The B7-1\/B7-2--CD28\/CTLA-4 and ICOS-B7RP-1 pathway provides key second signals that can regulate the activation, inhibition and fine-tuning of T-lymphocyte responses. ICOS stimulates both Th1 and Th2 cytokine production but may have a preferential role in Th2 cell development. Moreover, The B7-1\/B7-2-CD28\/CTLA-4 and ICOS-B7RP-1 pathway has been suggested of being involved in the development of airway inflammation and airway hyperresponsiveness.\n\nActivity: Immobilized human human B7-H2 at 1 μg\/ml (100 μl\/well) can bind human ICOS with a linear range of 1. 6-200 ng\/ml.\n\nSequence: Met 1-Phe 141\n\nPurity: \u0026gt; 90 % as determined by reducing SDS-PAGE.\n\nFormulation: Lyophilized from sterile PBS, pH 7.4\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\nPlease refer to the specific buffer information in the printed manual.\n\nReconstitution: Please refer to the printed manual for detailed information.\n\nEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\n\nCalculated MW: 41.6 kDa\n\nObserved MW: 50 kDa\n\nStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\n\nShipping: This product is provided as lyophilized powder which is shipped with ice packs.\n\nResearch Use Only","brand":"Elabscience","offers":[{"title":"Default Title","offer_id":43104320815283,"sku":"PKSH031664-100","price":1024.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_2f02a7f6-4a5e-4a40-8c64-d45f75442af0.png?v=1709294243","url":"https:\/\/afsbio.com\/products\/recombinant-human-icos-ailim-protein-his-fc-tagactive-pksh031664","provider":"AFSBio Inc.","version":"1.0","type":"link"}