{"product_id":"recombinant-human-ifn-λ3-il-28b-protein-human-cells-his-tagactive-pksh032637","title":"Recombinant Human IFN-λ3\/IL-28B Protein (Human Cells, His Tag)(Active) - PKSH032637","description":"\u003cp\u003eRecombinant Human IFN-λ3\/IL-28B Protein (Human Cells, His Tag)(Active)\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10μg, 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032637-10, PKSH032637-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IFN-λ3; IL-28B\u003c\/p\u003e\n\n\u003cp\u003eTarget Symptom: Interleukin-28B; IL-28B; Cytokine Zcyto22; Interferon Lambda-3; IFN-Lambda-3; Interferon Lambda-4; IFN-Lambda-4; Interleukin-28C; IL-28C; IL28B; IFNL3; IFNL4; IL28C; ZCYTO22\u003c\/p\u003e\n\n\u003cp\u003eResearch Area: Signal Transduction; Microbiology; immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eApplication: ELISA\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: Q8IZI9\u003c\/p\u003e\n\n\u003cp\u003eAccession: Q8IZI9\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interleukin-28B; also known as Cytokine Zcyto22; Interferon lambda-3; Interferon lambda-4; IFNL3; IFNL4; ZCYTO22 and IL28B; is a secreted cytokine which belongs to the IL-28\/IL-29 family. IL-28 has also been shown to play a role in the adaptive immune response. IL28B has immunomodulatory activity and up-regulates MHC class I antigen expression. IL28B displays potent antiviral activity and antitumor activity. In addition; IL28B is a ligand for the heterodimeric class II cytokine receptor composed of IL10RB and IL28RA. The ligand\/receptor complex seems to signal through the Jak-STAT pathway.\u003c\/p\u003e\n\n\u003cp\u003eActivity: Immobilized Human IL-28-His at 10μg\/ml(100 μl\/well) can bind Human IL-10RB-Fc(Cat: PKSH032564). The ED50 of Human IL-28-His is 0.37 ug\/ml.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Val22-Val196\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB; 150mM NaCl; 1mM EDTA; pH7.4.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 20.7 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 19 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"10μg","offer_id":43118147076275,"sku":"PKSH032637-10","price":249.2,"currency_code":"CAD","in_stock":true},{"title":"50μg","offer_id":43118147109043,"sku":"PKSH032637-50","price":732.2,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_5667b3a2-8072-4954-ac39-77a63c16af8f.png?v=1709637063","url":"https:\/\/afsbio.com\/products\/recombinant-human-ifn-%ce%bb3-il-28b-protein-human-cells-his-tagactive-pksh032637","provider":"AFSBio Inc.","version":"1.0","type":"link"}