{"product_id":"recombinant-human-ifn-lambda-2-il-28a-protein-rp00231","title":"Recombinant Human IFN-lambda 2\/IL-28A Protein - RP00231","description":"\u003cp\u003eRecombinant Human IFN-lambda 2\/IL-28A Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00231-10, RP00231-20, RP00231-50, RP00231-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human IFN-lambda 2\/IL-28A Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Val26-Val200) of human IL-28A\/IL28A (Accession #NP_742150.1) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IFNL2, IL-28A, IL28A, IFNL2a, IFNL3a, IL-28A\u003c\/p\u003e\n\n\u003cp\u003eSWISS: Q8IZJ0\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 282616\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 95 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: IL 28A (Interferon-lambda 2; IFN-lambda 2), IL-28B\/IFN-lambda 3, and IL-29\/IFN-lambda 1 are type III interferons which are distantly related to IL-10 family and type I IFN family cytokines. IL 28A ,interleukin 28B (IL28B), and interleukin 29 (IL29) are three closely related cytokine which are expression can be induced by viral infection.In the liver, the IL-28A induced Th1 cytokine response contributes to inflammation in T cell mediated hepatitis. IL-28A additionally exhibits anti-tumor activity, in part by enhancing IL-12 dependent anti-tumor CTL responses in vivo. In contrast, it is up-regulated in invasive bladder cancer where it promotes tumor cell migration.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: VPVARLHGALPDARGCHIAQFKSLSPQELQAFKRAKDALEESLLLKDCRCHSRLFPRTWDLRQLQVRERPMALEAELALTLKVLEATADTDPALVDVLDQPLHTLHHILSQFRACIQPQPTAGPRTRGRLHHWLYRLQEAPKKESPGCLEASVTFNLFRLLTRDLNCVASGDLCV\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198236582067,"sku":"RP00231-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198236614835,"sku":"RP00231-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198236647603,"sku":"RP00231-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198236680371,"sku":"RP00231-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_0b735aeb-94f6-4e1d-857b-ea1463cae570.png?v=1766959569","url":"https:\/\/afsbio.com\/products\/recombinant-human-ifn-lambda-2-il-28a-protein-rp00231","provider":"AFSBio Inc.","version":"1.0","type":"link"}