{"product_id":"recombinant-human-ifnar2-protein-his-tag-pksh032605","title":"Recombinant Human IFNAR2 Protein (His Tag) - PKSH032605","description":"\u003cp\u003eRecombinant Human IFNAR2 Protein (His Tag)\u003c\/p\u003e\n\n\u003cp\u003eSize: 50μg\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: PKSH032605-50\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eAbbreviation: IFNAR2\u003c\/p\u003e\n\n\u003cp\u003eTarget Synonym: Interferon Alpha\/Beta Receptor 2; IFN-R-2; IFN-Alpha Binding Protein; IFN-Alpha\/Beta Receptor 2; Interferon Alpha Binding Protein; Type I Interferon Receptor 2; IFNAR2; IFNABR; IFNARB\u003c\/p\u003e\n\n\u003cp\u003eUNIProt ID: P48551\u003c\/p\u003e\n\n\u003cp\u003eResearch Areas: Signal Transduction; Cancer; epigenetics and nuclear signal; immunology;\u003c\/p\u003e \n\n\u003cp\u003eTarget Species: Human\u003c\/p\u003e\n\n\u003cp\u003eExpression Host: HEK293 Cells\u003c\/p\u003e\n\n\u003cp\u003eFusion Tag: C-6His\u003c\/p\u003e\n\n\u003cp\u003eAccession: P48551\u003c\/p\u003e\n\n\u003cp\u003eBackground: Interferon α\/β Receptor 2 (IFN-α\/β R2) is a single-pass type I membrane protein which belongs to the type II cytokine receptor family. It complexes with IFN-α\/β R1 to form the signaling receptor complex for the family of α and β IFN subtypes. By alternative splicing; IFN-α\/β R2 can exist as a secreted soluble protein or as a type I membrane protein. IFN-α\/β R2 is the principal ligand binding subunit of the receptor. Ligand binding is stabilized by the subsequent association with IFN-α\/β R1; resulting in the formation of a signaling ternary receptor complex. IFNAR2 was detected in most lymphocytes; monocytes; and granulocytes; although IFNAR2 expression was higher in the monocytes and granulocytes than in the lymphocytes. Among the lymphocyte subsets; IFNAR2 showed high expression in natural killer (NK) cells and low expression in T lymphocytes. Isoform 1 and isoform 3 of IFNAR2 are directly involved in signal transduction due to their interaction with the TYR kinase; JAK1. Isoform 1 also interacts with the transcriptional factors; STAT1 and STAT2. Both forms are potent inhibitors of type I IFN activity.\u003c\/p\u003e\n\n\u003cp\u003eSequence: Ile27-Lys243\u003c\/p\u003e\n\n\u003cp\u003ePurity: \u0026gt; 95 % as determined by reducing SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, pH 7.2.\u003cbr\u003e\nNormally 5 % - 8 % trehalose, mannitol and 0.01% Tween80 are added as protectants before lyophilization.\u003cbr\u003e\nPlease refer to the specific buffer information in the printed manual.\u003c\/p\u003e\n\n\u003cp\u003eReconstitution: Please refer to the printed manual for detailed information.\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 1.0 EU per μg of the protein as determined by the LAL method.\u003c\/p\u003e\n\n\u003cp\u003eCalculated MW: 25.8 kDa\u003c\/p\u003e\n\n\u003cp\u003eObserved MW: 46 kDa\u003c\/p\u003e\n\n\u003cp\u003eStorage: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at \u0026lt; -20℃ for 3 months.\u003c\/p\u003e\n\n\u003cp\u003eShipping: This product is provided as lyophilized powder which is shipped with ice packs.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"Elabscience","offers":[{"title":"50μg","offer_id":43068865282227,"sku":"PKSH032605-50","price":366.8,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/products\/logo_new_82473081-8a24-4f92-9c6f-cac6c21a6219.png?v=1708598311","url":"https:\/\/afsbio.com\/products\/recombinant-human-ifnar2-protein-his-tag-pksh032605","provider":"AFSBio Inc.","version":"1.0","type":"link"}