{"product_id":"recombinant-human-igfbp-4-protein-rp00185","title":"Recombinant Human IGFBP-4 Protein - RP00185","description":"\u003cp\u003eRecombinant Human IGFBP-4 Protein\u003c\/p\u003e\n\n\u003cp\u003eSizes: 10ug, 20g, 50ug, 100ug\u003c\/p\u003e\n\n\u003cp\u003eCatalogue Numbers: RP00185-10, RP00185-20, RP00185-50, RP00185-100\u003c\/p\u003e\n\n\u003cp\u003eCitations, Manuals and MSDS Available upon request.\u003c\/p\u003e\n\n\u003cp\u003eDescription: Recombinant Human IGFBP-4 Protein is produced by HEK293 expression system. The target protein is expressed with sequence (Met1-Glu258) of human IGFBP-4 (Accession #NP_001543.2) fused with a 6×His tag at the C-terminus.\u003c\/p\u003e\n\n\u003cp\u003eAlternate Names: IGFBP4, BP-4, HT29-IGFBP, IBP4, IGFBP-4\u003c\/p\u003e\n\n\u003cp\u003eSWISS: P22692\u003c\/p\u003e\n\n\u003cp\u003eGeneID: 3487\u003c\/p\u003e\n\n\u003cp\u003eSpecies: Human\u003c\/p\u003e\n\n\u003cp\u003ePurity: ≥ 90 % as determined by SDS-PAGE.\u003c\/p\u003e\n\n\u003cp\u003eStorage: Store at -20 ℃. Store the lyophilized protein at -20℃ to -80 ℃ up to 1 year from the date of receipt. After reconstitution, the protein solution is stable at -20℃ for 3 months, at 2-8℃ for up to 1 week.\u003c\/p\u003e\n\n\u003cp\u003eBackground: IGFBP-4 (insulin-like growth factor binding protein 4) is member of the IGFBP family of structurally similar secreted glycoproteins. IGFBP-4 binds both insulin-like growth factor 1 (IGF-1) and IGF-2 with high affinity and inhibits IGF action in vitro. It circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. There is mounting evidence that IGFBP proteins plays a key role in the regulation of IGF bioavailability, by modulating its molecular size, capillary membrane permeability, target tissue specificity, cell membrane adherence and IGF affinity.\u003c\/p\u003e\n\n\u003cp\u003eBio-Activity: 1.Measured by its binding ability in a functional ELISA. Immobilized Human IGFBP4 at 1 μg\/mL (100 μL\/well) can bind Human IGF1 with a linear range of 1.95-111.32 ng\/mL.|2.Measured by its binding ability in a functional ELISA. Immobilized Human IGFBP4 Protein at 1 μg\/mL (100 μL\/well) can bind IGF1 with a linear range of 1.95-122.3ng\/mL.\u003c\/p\u003e\n\n\u003cp\u003eSource: HEK293 cells\u003c\/p\u003e\n\n\u003cp\u003eTag: C-His\u003c\/p\u003e\n\n\u003cp\u003eFormulation: Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4. Contact us for customized product form or formulation.\u003c\/p\u003e\n\n\u003cp\u003eAntigen Sequence: MLPLCLVAALLLAAGPGPSLGDEAIHCPPCSEEKLARCRPPVGCEELVREPGCGCCATCALGLGMPCGVYTPRCGSGLRCYPPRGVEKPLHTLMHGQGVCMELAEIEAIQESLQPSDKDEGDHPNNSFSPCSAHDRRCLQKHFAKIRDRSTSGGKMKVNGAPREDARPVPQGSCQSELHRALERLAASQSRTHEDLYIIPIPNCDRNGNFHPKQCHPALDGQRGKCWCVDRKTGVKLPGGLEPKGELDCHQLADSFRE\u003c\/p\u003e\n\n\u003cp\u003eEndotoxin: \u0026lt; 0.1 EU\/μg of the protein by LAL method.\u003c\/p\u003e\n\n\u003cp\u003eResearch Use Only\u003c\/p\u003e","brand":"ABclonal","offers":[{"title":"10ug","offer_id":45198301790387,"sku":"RP00185-10","price":210.0,"currency_code":"CAD","in_stock":true},{"title":"20ug","offer_id":45198301823155,"sku":"RP00185-20","price":280.0,"currency_code":"CAD","in_stock":true},{"title":"50ug","offer_id":45198301855923,"sku":"RP00185-50","price":350.0,"currency_code":"CAD","in_stock":true},{"title":"100ug","offer_id":45198301888691,"sku":"RP00185-100","price":560.0,"currency_code":"CAD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0305\/9482\/6376\/files\/download_33bad1c4-3735-48ca-a5a1-0aa0111df1e0.png?v=1766960337","url":"https:\/\/afsbio.com\/products\/recombinant-human-igfbp-4-protein-rp00185","provider":"AFSBio Inc.","version":"1.0","type":"link"}